Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHUK | O15111 | 1/20 | 0.56 |
| ▸ | KIF11 | P52732 | 10/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | GSK3A | P49840 | 2/20 | 0.41 |
| ▸ | GSK3B | P49841 | 2/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.41 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17358501 | 0.88 | KIF11 (0.65) | CHUKKIF11KDM4EMEN1KMT2A | |
| SCHEMBL17407762 | 0.81 | CHUK (0.40) | CHUKKIF11 | |
| SCHEMBL29507666 | 0.80 | KIF11 (0.81) | CHUKKIF11KDM4EMEN1KMT2A | |
| SCHEMBL412032 | 0.80 | KIF11 (0.81) | CHUKKIF11KDM4EMEN1KMT2A | |
| SCHEMBL18858433 | 0.80 | KIF11 (0.40) | CHUKKIF11 | |
| SCHEMBL13772413 | 0.77 | CHUK (0.50) | CHUKKIF11KDM4EMEN1KMT2A | |
| SCHEMBL17407763 | 0.77 | KIF11 (0.40) | CHUKKIF11KDM4E | |
| SCHEMBL17396540 | 0.75 | CHUK (0.63) | CHUKKIF11KDM4EMEN1KMT2A | |
| SCHEMBL15109739 | 0.75 | HTR1A (0.53) | — | |
| SCHEMBL15109738 | 0.75 | HTR1A (0.53) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3459944-B1 | AZEPANYL-DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME WITH ANTIPARASITIC ACTIVITY | MERCK PATENT GMBH (DE) | 2021-01-06 | — | — | EP | disclosed |
| EP-3459944-B1 | AZEPANYL-DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME WITH ANTIPARASITIC ACTIVITY | MERCK PATENT GMBH (DE) | 2021-01-06 | — | — | EP | disclosed |
| CN-111533734-A | Azepanyl derivatives having antiparasitic activity and pharmaceutical compositions containing them | 默克专利股份有限公司 | 2020-08-14 | — | — | CN | disclosed |
| CN-106573918-B | Azepanyl derivatives having antiparasitic activity and pharmaceutical compositions containing them | 默克专利股份有限公司 | 2020-06-16 | — | — | CN | disclosed |
| EP-3459944-A1 | AZEPANYL-DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME WITH ANTIPARASITIC ACTIVITY | Merck Patent GmbH (DE) | 2019-03-27 | — | — | EP | disclosed |
| EP-3459944-A1 | AZEPANYL-DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME WITH ANTIPARASITIC ACTIVITY | Merck Patent GmbH (DE) | 2019-03-27 | — | — | EP | disclosed |
| EP-3164397-B1 | AZEPANYL-DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME WITH ANTIPARASITIC ACTIVITY | MERCK PATENT GMBH (DE) | 2018-12-19 | — | — | EP | disclosed |
| US-9994577-B2 | Azepanyl-derivatives and pharmaceutical compositions comprising the same with antiparasitic activity | MERCK PATENT GMBH (DE) | 2018-06-12 | — | — | US | disclosed |
| US-9994577-B2 | Azepanyl-derivatives and pharmaceutical compositions comprising the same with antiparasitic activity | MERCK PATENT GMBH (DE) | 2018-06-12 | — | — | US | disclosed |
| US-9994577-B2 | Azepanyl-derivatives and pharmaceutical compositions comprising the same with antiparasitic activity | MERCK PATENT GMBH (DE) | 2018-06-12 | — | — | US | disclosed |
| US-9908863-B2 | Piperidinylcarbazoles | MERCK PATENT GMBH (DE) | 2018-03-06 | — | — | US | disclosed |
| US-20170137428-A1 | AZEPANYL-DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME WITH ANTIPARASITIC ACTIVITY | MERCK PATENT GMBH (DE) | 2017-05-18 | — | — | US | disclosed |
| US-20170137428-A1 | AZEPANYL-DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME WITH ANTIPARASITIC ACTIVITY | MERCK PATENT GMBH (DE) | 2017-05-18 | — | — | US | disclosed |
| US-20170137428-A1 | AZEPANYL-DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME WITH ANTIPARASITIC ACTIVITY | MERCK PATENT GMBH (DE) | 2017-05-18 | — | — | US | disclosed |
| EP-3164397-A1 | AZEPANYL-DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME WITH ANTIPARASITIC ACTIVITY | Merck Patent GmbH (DE) | 2017-05-10 | — | — | EP | disclosed |
| WO-2016000827-A1 | AZEPANYL-DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME WITH ANTIPARASITIC ACTIVITY | MERCK PATENT GMBH (DE) | 2016-01-07 | — | — | WO | disclosed |
| WO-2016000827-A1 | AZEPANYL-DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME WITH ANTIPARASITIC ACTIVITY | MERCK PATENT GMBH (DE) | 2016-01-07 | — | — | WO | disclosed |
| US-20150368226-A1 | PIPERIDINYLCARBAZOLES | MERCK PATENT GMBH (DE) | 2015-12-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170137428-A1 | AZEPANYL-DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS COMPRISING THE SAME WITH ANTIPARASITIC ACTIVITY | ACHE, PARK7, CYP51A1 | CHUK 4243/4885KIF11 1584/4885KDM4E 1438/4885 |
| US-20150368226-A1 | PIPERIDINYLCARBAZOLES | PSEN1, ARG2, UQCRC1 | CHUK 4226/4885KIF11 3888/4885KDM4E 812/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.