Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 2/20 | 0.36 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.36 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.36 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.36 |
| ▸ | GPR88 | Q9GZN0 | 2/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 4/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | KIF11 | P52732 | 2/20 | 0.33 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.33 |
| ▸ | PPARD | Q03181 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17359590 | 0.85 | PLA2G2A (0.40) | PLA2G2APLA2G10PLA2G1BPLA2G5KIF11 | |
| SCHEMBL17359609 | 0.73 | PLA2G2A (0.33) | PLA2G2APLA2G10PLA2G1BPLA2G5GPR88 | |
| SCHEMBL18609340 | 0.72 | PLA2G2A (0.49) | PLA2G2APLA2G10PLA2G1BPLA2G5KIF11 | |
| SCHEMBL15895042 | 0.69 | PLA2G2A (0.40) | PLA2G2APLA2G10PLA2G1BPLA2G5GPR88 | |
| SCHEMBL17359776 | 0.69 | PLA2G2A (0.39) | PLA2G2APLA2G10PLA2G1BPLA2G5KIF11 | |
| SCHEMBL3398385 | 0.69 | KIF11 (0.59) | TSHRTDP1L3MBTL1KIF11 | |
| SCHEMBL18912718 | 0.69 | PLA2G2A (0.55) | PLA2G2APLA2G10PLA2G1BPLA2G5HDAC6 | |
| SCHEMBL8353837 | 0.68 | PLA2G2A (0.53) | PLA2G2APLA2G10PLA2G1BPLA2G5ALDH1A1 | |
| SCHEMBL8195323 | 0.68 | PLA2G2A (0.53) | PLA2G2APLA2G10PLA2G1BPLA2G5ALDH1A1 | |
| SCHEMBL8356181 | 0.68 | PLA2G2A (0.53) | PLA2G2APLA2G10PLA2G1BPLA2G5ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150366887-A1 | SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF | Janssen Pharmaceuticals, Inc. | 2015-12-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150366887-A1 | SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF | PNP, NUDT1, NT5C3B | PLA2G2A 2939/4885PLA2G10 2487/4885PLA2G1B 2210/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.