Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 2/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | GRIN1 | Q05586 | 8/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 8/20 | 0.37 |
| ▸ | GLO1 | Q04760 | 3/20 | 0.36 |
| ▸ | ATR | Q13535 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17362391 | 0.83 | GRIN2B (0.35) | APPGRIN1GRIN2BGLO1 | |
| SCHEMBL14467094 | 0.82 | APP (0.49) | APPHSD11B1PIK3CAMTORGLO1 | |
| SCHEMBL15916486 | 0.82 | GLO1 (0.45) | GRIN1GRIN2BGLO1 | |
| SCHEMBL17362285 | 0.79 | ALOX5AP (0.41) | APPHSD11B1 | |
| SCHEMBL24720893 | 0.74 | APP (0.42) | APPPIK3CAMTORGRIN1GRIN2B | |
| SCHEMBL13005158 | 0.74 | ALOX5AP (0.48) | APPPIK3CAMTORATR | |
| SCHEMBL17362343 | 0.70 | HCAR1 (0.39) | GRIN1GRIN2B | |
| SCHEMBL24719738 | 0.69 | TOP2A (0.42) | APPPIK3CAMTOR | |
| SCHEMBL22781685 | 0.69 | APP (0.48) | APPPIK3CAMTORGRIN1GRIN2B | |
| SCHEMBL17362135 | 0.68 | GRIN2B (0.44) | GRIN1GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9745328-B2 | Flap modulators | JANSSEN PHARMACEUTICA NV (BE) | 2017-08-29 | — | — | US | disclosed |
| US-20150376212-A1 | FLAP MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-12-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150376212-A1 | FLAP MODULATORS | FEN1, PGF, TBXA2R | APP 4656/4885HSD11B1 173/4885PIK3CA 203/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.