Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 13/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 12/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17362187 | 0.83 | APP (0.47) | GRIN2BGRIN1GLO1APP | |
| SCHEMBL17362346 | 0.82 | USP1 (0.33) | MAPTHSD17B10LMNAALOX5APFEN1 | |
| SCHEMBL17362135 | 0.81 | GRIN2B (0.44) | GRIN2BGRIN1 | |
| SCHEMBL17362387 | 0.81 | ALOX5AP (0.39) | GRIN2BMAPTCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL17362343 | 0.80 | HCAR1 (0.39) | GRIN2BGRIN1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL21167296 | 0.79 | APP (0.36) | GLO1APP | |
| SCHEMBL15916486 | 0.77 | GLO1 (0.45) | GRIN2BGRIN1GLO1 | |
| SCHEMBL17362288 | 0.75 | ALDH1A1 (0.33) | HSD17B10CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL17362242 | 0.73 | ALOX5AP (0.39) | MAPTHSD17B10ALOX5APFEN1 | |
| SCHEMBL22388539 | 0.69 | CNR2 (0.36) | APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9745328-B2 | Flap modulators | JANSSEN PHARMACEUTICA NV (BE) | 2017-08-29 | — | — | US | disclosed |
| US-20150376212-A1 | FLAP MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-12-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150376212-A1 | FLAP MODULATORS | FEN1, PGF, TBXA2R | GRIN2B 3381/4885GRIN1 2139/4885MAPT 4864/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.