Sugi Predict

Sugi Predict / Compounds / SCHEMBL1736369

SCHEMBL1736369

SCHEMBL1736369

Cc1[nH]c2c(COc3ccccc3Cl)nccc2c1C

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM5A P29375 1/20 0.41
▸ KDM4C Q9H3R0 1/20 0.41
▸ KDM5B Q9UGL1 1/20 0.41
▸ CYP1A2 P05177 1/20 0.41
▸ CYP3A4 P08684 1/20 0.41
▸ CYP2C9 P11712 1/20 0.41
▸ CYP2C19 P33261 1/20 0.41
▸ AHR P35869 1/20 0.39
▸ FFAR1 O14842 1/20 0.39
▸ MAPT P10636 5/20 0.38
▸ KDM4E B2RXH2 4/20 0.38
▸ CDC7 O00311 1/20 0.38
▸ PLK4 O00444 1/20 0.38
▸ DYRK3 O43781 1/20 0.38
▸ ROCK2 O75116 1/20 0.38
▸ MAP4K4 O95819 1/20 0.38
▸ ROS1 P08922 1/20 0.38
▸ PRKACA P17612 1/20 0.38
▸ RPS6KB1 P23443 1/20 0.38
▸ MARK3 P27448 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL1738954 0.81 CYP1A2 (0.35) KDM5AKDM4CKDM5BCYP1A2CYP3A4
SCHEMBL1737740 0.79 CYP1A2 (0.40) CYP1A2CYP3A4CYP2C9CYP2C19AHR
Hydrochloric Acid SCHEMBL1735317 0.78 CYP1A2 (0.39) CYP1A2CYP3A4CYP2C9CYP2C19AHR
SCHEMBL1736488 0.78 TRPA1 (0.44) CYP1A2CYP3A4CYP2C9CYP2C19FFAR1
SCHEMBL1736542 0.77 L3MBTL1 (0.41) CYP1A2CYP3A4CYP2C9CYP2C19AHR
SCHEMBL1736493 0.76 CYP1A2 (0.40) KDM4CCYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL5806654 0.74 MPO (0.42) CYP1A2CYP3A4CYP2C9CYP2C19AHR
SCHEMBL1739165 0.73 KDM4E (0.40) FFAR1MAPTKDM4ECDC7PLK4
Hydrochloric Acid SCHEMBL1738287 0.73 HTR1A (0.34) KDM5AKDM4CKDM5BFFAR1MAPT
SCHEMBL5810147 0.73 CYP1A2 (0.47) CYP1A2CYP3A4CYP2C9CYP2C19AHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1784404-B1 PYRROLO[2,3-C]PYRIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF YUHAN CORP (KR) 2011-11-16 — — EP claimed
US-20110263306-A1 COMPUTER SYSTEM AND PROGRAM NAMCO BANDAI GAMES INC. (JP) 2011-10-27 — — US claimed
CN-101018789-B Pyrrolo[2,3-c]pyridine derivatives and processes for the preparation thereof YUHAN CORP 2010-09-08 — — CN claimed
US-7662832-B2 Pyrrolo[2,3-c]pyridine derivatives and processes for the preparation thereof YUHAN CORPORATION (KR) 2010-02-16 — — US claimed
EP-1784404-A4 PYRROLO[2,3-C]PYRIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF YUHAN CORP (KR) 2009-09-09 — — EP claimed
JP-2008511621-A — — 2008-04-17 — — JP claimed
US-20070219230-A1 PYRROLO[2,3-C]PYRIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF YUHAN CORPORATION (KR) 2007-09-20 — — US claimed
CN-101018789-A Pyrrolo[2,3-c]pyridine derivatives and processes for the preparation thereof YUHAN CORP (KR) 2007-08-15 — — CN claimed
EP-1784404-A1 PYRROLO[2,3-C]PYRIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF Yuhan Corporation (KR) 2007-05-16 — — EP claimed
WO-2006025716-A1 PYRROLO[2,3-C]PYRIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF YUHAN CORPORATION (KR) 2006-03-09 — — WO claimed
US-8188114-B2 Pyrrolo[2,3-C]pyridine derivatives and processes for the preparation thereof YUHAN CORPORATION (KR) 2012-05-29 — — US disclosed
EP-1784404-B1 PYRROLO[2,3-C]PYRIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF YUHAN CORP (KR) 2011-11-16 — — EP disclosed
US-20110263306-A1 COMPUTER SYSTEM AND PROGRAM NAMCO BANDAI GAMES INC. (JP) 2011-10-27 — — US disclosed
CN-101018789-B Pyrrolo[2,3-c]pyridine derivatives and processes for the preparation thereof YUHAN CORP 2010-09-08 — — CN disclosed
US-20100069430-A1 PYRROLO[2,3-C]PYRIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF YUHAN CORPORATION (KR) 2010-03-18 — — US disclosed
EP-1784404-A4 PYRROLO[2,3-C]PYRIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF YUHAN CORP (KR) 2009-09-09 — — EP disclosed
US-20070219230-A1 PYRROLO[2,3-C]PYRIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF YUHAN CORPORATION (KR) 2007-09-20 — — US disclosed
CN-101018789-A Pyrrolo[2,3-c]pyridine derivatives and processes for the preparation thereof YUHAN CORP (KR) 2007-08-15 — — CN disclosed
EP-1784404-A1 PYRROLO[2,3-C]PYRIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF Yuhan Corporation (KR) 2007-05-16 — — EP disclosed
WO-2006025716-A1 PYRROLO[2,3-C]PYRIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF YUHAN CORPORATION (KR) 2006-03-09 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100069430-A1 PYRROLO[2,3-C]PYRIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF PGA5, ATP6AP1, ATP6V1H KDM5A 1334/4885KDM4C 927/4885KDM5B 1163/4885
US-20070219230-A1 PYRROLO[2,3-C]PYRIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF PGA5, ATP6AP1, ATP6V1H KDM5A 1334/4885KDM4C 927/4885KDM5B 1163/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.