Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNP | P00491 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 11/20 | 0.34 |
| ▸ | JAK1 | P23458 | 7/20 | 0.33 |
| ▸ | KDM4A | O75164 | 1/20 | 0.33 |
| ▸ | KDM4B | O94953 | 1/20 | 0.33 |
| ▸ | KDM5C | P41229 | 1/20 | 0.33 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.33 |
| ▸ | IKBKB | O14920 | 1/20 | 0.33 |
| ▸ | CHUK | O15111 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 4/20 | 0.31 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.31 |
| ▸ | DAPK3 | O43293 | 3/20 | 0.31 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.31 |
| ▸ | PAK4 | O96013 | 3/20 | 0.31 |
| ▸ | CSF1R | P07333 | 3/20 | 0.31 |
| ▸ | RET | P07949 | 3/20 | 0.31 |
| ▸ | MET | P08581 | 3/20 | 0.31 |
| ▸ | PIM1 | P11309 | 3/20 | 0.31 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.31 |
| ▸ | PRKACA | P17612 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7022512 | 0.79 | CDK5 (0.44) | JAK2JAK3MAP4K4DAPK3PRKD3 | |
| SCHEMBL7027243 | 0.69 | JAK2 (0.33) | JAK2JAK1KDM4AKDM4BKDM5C | |
| SCHEMBL7027575 | 0.69 | ITK (0.48) | RETKDRGSK3BAURKAABL1 | |
| SCHEMBL2938674 | 0.68 | JAK2 (0.54) | JAK2JAK3MAP4K4PRKD3PAK4 | |
| SCHEMBL1900509 | 0.66 | NEK2 (0.38) | JAK2IKBKBCHUKPRKACABRD4 | |
| SCHEMBL18486378 | 0.65 | TOP2A (0.49) | LIMK1 | |
| Adenine SCHEMBL1065182 | 0.65 | MAP4K4 (0.41) | PNPMAP4K4DYRK1ALRRK2PARP1 | |
| Adenine SCHEMBL19974438 | 0.65 | MAP4K4 (0.41) | PNPMAP4K4DYRK1ALRRK2PARP1 | |
| Adenine SCHEMBL4579285 | 0.65 | MAP4K4 (0.41) | PNPMAP4K4DYRK1ALRRK2PARP1 | |
| SCHEMBL17364297 | 0.65 | ULK1 (0.44) | CDK7DYRK1ALRRK2CDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150376219-A1 | Selective Preparations of Purine Nucleosides and Nucleotides: Reagents and Methods | ZHONG MINGHONG (US) | 2015-12-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150376219-A1 | Selective Preparations of Purine Nucleosides and Nucleotides: Reagents and Methods | PNP, ATIC, NT5C3B | PNP 1/4885JAK2 3681/4885JAK1 4490/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.