SCHEMBL17378371

SCHEMBL17378371

COC(=O)CNC1=C(OC)C(Cl)=CCC1

nearest known ligand 0.34

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ KMT2A Q03164 3/20 0.34
▸ MEN1 O00255 2/20 0.34
▸ ALDH1A1 P00352 2/20 0.34
▸ POLB P06746 1/20 0.34
▸ SMN1; SMN2 Q16637 2/20 0.32
▸ GAA P10253 3/20 0.32
▸ KDM4E B2RXH2 1/20 0.32
▸ MKNK1 Q9BUB5 1/20 0.31
▸ MKNK2 Q9HBH9 1/20 0.31
▸ HSD17B10 Q99714 1/20 0.31
▸ NLRP3 Q96P20 1/20 0.31
▸ CA12 O43570 1/20 0.30
▸ CA1 P00915 1/20 0.30
▸ CA2 P00918 1/20 0.30
▸ CA9 Q16790 1/20 0.30
▸ CA14 Q9ULX7 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18803284 0.71 NLRP3 (0.35) KMT2AMEN1ALDH1A1SMN1; SMN2GAA
SCHEMBL2523214 0.63 KDM4E (0.49) KMT2AMEN1ALDH1A1SMN1; SMN2GAA
SCHEMBL1417236 0.62 POLB (0.48) KMT2AMEN1ALDH1A1POLBSMN1; SMN2
SCHEMBL29512022 0.62 POLB (0.48) KMT2AMEN1ALDH1A1POLBSMN1; SMN2
SCHEMBL2237455 0.61 — —
SCHEMBL22984920 0.61 TSHR (0.44) KMT2AMEN1ALDH1A1POLBSMN1; SMN2
SCHEMBL5121422 0.60 ALDH1A1 (0.61) KMT2AMEN1ALDH1A1POLBGAA
SCHEMBL29035804 0.60 KMT2A (0.36) KMT2AMEN1ALDH1A1POLBSMN1; SMN2
SCHEMBL19264696 0.60 SLC6A3 (0.40) NLRP3
Hydrochloric Acid SCHEMBL29771988 0.60 POLB (0.47) KMT2AMEN1ALDH1A1POLBSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3164196-B1 TOPICAL FORMULATIONS FOR UV PROTECTION TOPGENIX INC (US) 2021-08-18 — — EP disclosed
US-20170119641-A1 TOPICAL FORMULATIONS FOR UV PROTECTION TopGeniX, Inc. 2017-05-04 — — US disclosed
US-20170119641-A1 TOPICAL FORMULATIONS FOR UV PROTECTION TopGeniX, Inc. 2017-05-04 — — US disclosed
WO-2015195546-A1 TOPICAL FORMULATIONS FOR UV PROTECTION TopGeniX, Inc. (US) 2015-12-23 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170119641-A1 TOPICAL FORMULATIONS FOR UV PROTECTION ERCC4, ERCC1, UNG KMT2A 4590/4885MEN1 3883/4885ALDH1A1 417/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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