Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 6/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.46 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | CASP1 | P29466 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3843266 | 0.82 | FABP4 (0.52) | ALDH1A1HPGDHSD17B10CLCN2 | |
| SCHEMBL10647665 | 0.82 | SMN1; SMN2 (0.39) | KDM4EALDH1A1HPGDSMN1; SMN2POLB | |
| SCHEMBL7223232 | 0.81 | KDM4E (0.54) | SIRT2KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL14215791 | 0.81 | CES1 (0.45) | KDM4EALDH1A1SMN1; SMN2POLBMAPT | |
| Fluoride Ion SCHEMBL10900121 | 0.79 | PDK1 (0.37) | KDM4EALDH1A1HPGDSMN1; SMN2POLB | |
| SCHEMBL8645992 | 0.78 | KDM4E (0.55) | SIRT2KDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL10424663 | 0.77 | SIRT2 (0.62) | SIRT2KDM4EALDH1A1HPGDMAPT | |
| SCHEMBL9921482 | 0.77 | KDM4E (0.56) | SIRT2KDM4EALDH1A1HPGDAGTR1 | |
| SCHEMBL175535 | 0.77 | KDM4E (0.56) | SIRT2KDM4EALDH1A1HPGDAGTR1 | |
| SCHEMBL5517881 | 0.76 | CDC7 (0.44) | SIRT2KDM4EALDH1A1AGTR1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107325019-B | Aryl amine benzamide compound and N- aryl-aryl amine benzamide compound preparation method | 石河子大学 | 2019-11-22 | — | — | CN | disclosed |
| CN-107325019-A | The preparation method of aryl amine benzamide compound and N aryl aryl amine benzamide compounds | 石河子大学 | 2017-11-07 | — | — | CN | disclosed |
| US-8633207-B2 | Quinazoline compounds and methods of use thereof | AMBIT BIOSCIENCES CORPORATION (US) | 2014-01-21 | — | — | US | disclosed |
| EP-2611789-A1 | QUINAZOLINE COMPOUNDS AND METHODS OF USE THEREOF | Ambit Biosciences Corporation (US) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012030948-A1 | QUINAZOLINE COMPOUNDS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORPORATION (US) | 2012-03-08 | — | — | WO | disclosed |
| US-20120053174-A1 | QUINAZOLINE COMPOUNDS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORPORATION | 2012-03-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120053174-A1 | QUINAZOLINE COMPOUNDS AND METHODS OF USE THEREOF | JAK3, JAK2, TYK2 | SIRT2 1153/4885KDM4E 1840/4885ALDH1A1 4588/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.