Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 12/20 | 0.47 |
| ▸ | LMNA | P02545 | 6/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.46 |
| ▸ | HTT | P42858 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 8/20 | 0.45 |
| ▸ | NPC1 | O15118 | 7/20 | 0.45 |
| ▸ | MAPT | P10636 | 6/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MITF | O75030 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 4/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | GRM5 | P41594 | 1/20 | 0.42 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17398056 | 0.86 | LMNA (0.39) | ALDH1A1LMNASMN1; SMN2HTTMAPT | |
| SCHEMBL17398003 | 0.84 | HDAC9 (0.39) | ALDH1A1LMNASMN1; SMN2HTTRAB9A | |
| SCHEMBL17397915 | 0.78 | SMN1; SMN2 (0.48) | ALDH1A1LMNASMN1; SMN2HTTRAB9A | |
| SCHEMBL17397920 | 0.77 | ALDH1A1 (0.50) | ALDH1A1LMNASMN1; SMN2HTTRAB9A | |
| SCHEMBL17398012 | 0.77 | ALDH1A1 (0.48) | ALDH1A1LMNASMN1; SMN2HTTRAB9A | |
| SCHEMBL17398063 | 0.76 | SMN1; SMN2 (0.46) | ALDH1A1LMNASMN1; SMN2HTTRAB9A | |
| SCHEMBL17397958 | 0.74 | ITK (0.46) | ALDH1A1LMNASMN1; SMN2HTTRAB9A | |
| SCHEMBL17398079 | 0.73 | KMT2A (0.39) | ALDH1A1LMNASMN1; SMN2HTTRAB9A | |
| SCHEMBL17398031 | 0.70 | KDM4E (0.44) | ALDH1A1LMNASMN1; SMN2HTTRAB9A | |
| SCHEMBL17397926 | 0.70 | KDR (0.49) | ALDH1A1HTTHPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016001341-A1 | SULFONYLAMINOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2016-01-07 | — | — | WO | disclosed |