Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MAT2A | P31153 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | TCF4 | P15884 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17397982 | 0.82 | ALDH1A1 (0.43) | KDM4EHTTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL17398026 | 0.79 | ITK (0.48) | KDM4EGAAHTTMEN1KMT2A | |
| SCHEMBL17398060 | 0.79 | AURKA (0.46) | — | |
| SCHEMBL17398074 | 0.78 | WDR5 (0.43) | GAAKMT2ALMNA | |
| SCHEMBL17398027 | 0.76 | KDM4E (0.50) | KDM4EGAAHTTMEN1KMT2A | |
| SCHEMBL17397937 | 0.75 | HTR6 (0.43) | KDM4EGAAHTTKMT2ASMN1; SMN2 | |
| SCHEMBL17397958 | 0.75 | ITK (0.46) | KDM4EHTTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL17398018 | 0.75 | MAPT (0.44) | KDM4EGAASMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL17397920 | 0.74 | ALDH1A1 (0.50) | HTTMEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL17398012 | 0.74 | ALDH1A1 (0.48) | GAAHTTMEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016001341-A1 | SULFONYLAMINOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2016-01-07 | — | — | WO | disclosed |