Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 5/20 | 0.48 |
| ▸ | NPC1 | O15118 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | CASP3 | P42574 | 1/20 | 0.48 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.48 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.48 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.48 |
| ▸ | ITK | Q08881 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CRHBP | P24387 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.43 |
| ▸ | CDK2 | P24941 | 4/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | WDR5 | P61964 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17398012 | 0.81 | ALDH1A1 (0.48) | ALDH1A1RAB9ANPC1SMN1; SMN2MEN1 | |
| SCHEMBL17397958 | 0.78 | ITK (0.46) | ALDH1A1RAB9ANPC1SMN1; SMN2MEN1 | |
| SCHEMBL17397918 | 0.77 | ALDH1A1 (0.47) | ALDH1A1RAB9ANPC1SMN1; SMN2MEN1 | |
| SCHEMBL17397919 | 0.76 | ITK (0.63) | ALDH1A1RAB9ANPC1SMN1; SMN2MEN1 | |
| SCHEMBL17398079 | 0.76 | KMT2A (0.39) | ALDH1A1RAB9ANPC1SMN1; SMN2MEN1 | |
| SCHEMBL17398056 | 0.75 | LMNA (0.39) | ALDH1A1SMN1; SMN2MEN1KMT2AMAPT | |
| SCHEMBL17398031 | 0.74 | KDM4E (0.44) | ALDH1A1RAB9ANPC1SMN1; SMN2MEN1 | |
| SCHEMBL17397926 | 0.73 | KDR (0.49) | ALDH1A1HTT | |
| SCHEMBL17398003 | 0.73 | HDAC9 (0.39) | ALDH1A1RAB9ANPC1SMN1; SMN2MEN1 | |
| SCHEMBL17397982 | 0.70 | ALDH1A1 (0.43) | ALDH1A1RAB9ANPC1SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016001341-A1 | SULFONYLAMINOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2016-01-07 | — | — | WO | disclosed |