Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | GLP1R | P43220 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | IDH1 | O75874 | 1/20 | 0.33 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | ATR | Q13535 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.31 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.31 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.31 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31646729 | 0.80 | SMN1; SMN2 (0.35) | SMN1; SMN2MAPTGLP1RALDH1A1NPSR1 | |
| SCHEMBL21959011 | 0.78 | LOX (0.39) | POLBMAPTALDH1A1ABL1L3MBTL1 | |
| SCHEMBL31646986 | 0.78 | MMP1 (0.35) | MAPTGLP1RALDH1A1NPSR1S1PR2 | |
| SCHEMBL13797492 | 0.77 | POLB (0.39) | POLBMAPTALDH1A1S1PR1PSEN1 | |
| SCHEMBL21469881 | 0.75 | PTGS2 (0.41) | SMN1; SMN2GLP1RALDH1A1S1PR2 | |
| SCHEMBL13749011 | 0.74 | CA1 (0.34) | NR1H2NR1H3POLBMAPTGLP1R | |
| SCHEMBL13754869 | 0.74 | L3MBTL1 (0.35) | NR1H2NR1H3POLBMAPTALDH1A1 | |
| SCHEMBL7629665 | 0.72 | KDM4E (0.36) | MAPTGLP1RALDH1A1NPSR1 | |
| SCHEMBL21143703 | 0.72 | ALDH1A1 (0.46) | MAPTALDH1A1S1PR2S1PR1 | |
| SCHEMBL14648623 | 0.70 | L3MBTL1 (0.38) | MAPTALDH1A1NPSR1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016001341-A1 | SULFONYLAMINOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2016-01-07 | — | — | WO | disclosed |
| WO-2016001341-A1 | SULFONYLAMINOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2016-01-07 | — | — | WO | disclosed |