Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 2/20 | 0.41 |
| ▸ | HTR6 | P50406 | 9/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | IGF1R | P08069 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17397937 | 0.80 | HTR6 (0.43) | HTR6HTR2BHTTL3MBTL1POLB | |
| SCHEMBL17413517 | 0.79 | HTR6 (0.41) | ITKHTR6HTR2BPOLBALDH1A1 | |
| SCHEMBL17398025 | 0.79 | ITK (0.63) | ITKHTR6HTTL3MBTL1ALDH1A1 | |
| SCHEMBL17398058 | 0.77 | AURKA (0.49) | ITKIGF1R | |
| SCHEMBL17397980 | 0.77 | ALDH1A1 (0.44) | ITKHTR6HTTL3MBTL1POLB | |
| SCHEMBL17398027 | 0.76 | KDM4E (0.50) | ITKHTTPOLBALDH1A1KDM4E | |
| SCHEMBL17398010 | 0.74 | ALDH1A1 (0.48) | ITKHTTL3MBTL1ALDH1A1PKM | |
| SCHEMBL17398075 | 0.74 | ITK (0.42) | ITKHTR6HTTL3MBTL1ALDH1A1 | |
| SCHEMBL17398072 | 0.73 | ITK (0.47) | ITKHTR6HTTALDH1A1KDM4E | |
| SCHEMBL17397956 | 0.73 | ITK (0.64) | ITKHTTL3MBTL1POLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016001341-A1 | SULFONYLAMINOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2016-01-07 | — | — | WO | disclosed |
| WO-2016001341-A1 | SULFONYLAMINOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2016-01-07 | — | — | WO | disclosed |