Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALKBH3 | Q96Q83 | 3/20 | 0.38 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | HTT | P42858 | 3/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20841748 | 0.97 | ALKBH3 (0.41) | ALKBH3LTB4RSMN1; SMN2GABRA1GABRB2 | |
| SCHEMBL17407641 | 0.94 | CDC7 (0.43) | ALKBH3LTB4RSMN1; SMN2GABRA1GABRB2 | |
| SCHEMBL492636 | 0.93 | LTB4R (0.41) | ALKBH3LTB4RSMN1; SMN2POLBRAB9A | |
| SCHEMBL10196888 | 0.93 | ABCB1 (0.39) | ALKBH3SMN1; SMN2GABRA1GABRB2POLB | |
| SCHEMBL20841761 | 0.93 | ABCB1 (0.39) | ALKBH3SMN1; SMN2GABRA1GABRB2POLB | |
| SCHEMBL24329824 | 0.93 | ADORA3 (0.39) | ALKBH3SMN1; SMN2TP53GABRA1GABRB2 | |
| SCHEMBL19206667 | 0.92 | LTB4R (0.39) | ALKBH3LTB4RRAB9AALDH1A1KDM4E | |
| SCHEMBL13484442 | 0.91 | ALDH1A1 (0.42) | SMN1; SMN2TP53POLBRAB9ANPC1 | |
| SCHEMBL17299341 | 0.91 | ALKBH3 (0.38) | ALKBH3SMN1; SMN2TP53GABRA1GABRB2 | |
| SCHEMBL20543611 | 0.90 | THRB (0.42) | ALKBH3SMN1; SMN2TP53THRBRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160002703-A1 | IMIDAZO[1,2-alpha]PYRAZINE DERIVATIVES | JPMORGAN CHASE BANK, N.A., AS COLLATERAL AGENT | 2016-01-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160002703-A1 | IMIDAZO[1,2-alpha]PYRAZINE DERIVATIVES | GLB1, NISCH, BOLA2; BOLA2B | ALKBH3 4617/4885LTB4R 558/4885SMN1; SMN2 4689/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.