Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.36 |
| ▸ | POLB | P06746 | 4/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 5/20 | 0.33 |
| ▸ | MAPT | P10636 | 5/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6496460 | 0.98 | — | — | |
| Hydrochloric Acid SCHEMBL7377383 | 0.96 | ALOX5 (0.38) | ALOX5KMT2APOLBL3MBTL1PKM | |
| Hydrochloric Acid SCHEMBL7480806 | 0.94 | ALOX5 (0.37) | ALOX5KMT2APOLBL3MBTL1PKM | |
| SCHEMBL10806343 | 0.76 | — | — | |
| SCHEMBL9782148 | 0.76 | — | — | |
| SCHEMBL8392647 | 0.75 | KMT2A (0.40) | ALOX5KMT2APOLBL3MBTL1PKM | |
| SCHEMBL5582099 | 0.71 | — | — | |
| SCHEMBL8935129 | 0.71 | — | — | |
| SCHEMBL27536763 | 0.71 | — | — | |
| SCHEMBL9669855 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3405034-B1 | PROCESS FOR THE PREPARATION OF 4-ALKOXY-3-HYDROXYPICOLINIC ACIDS | DOW AGROSCIENCES LLC (US) | 2021-05-12 | — | — | EP | disclosed |
| EP-3166611-B1 | PROCESS FOR THE PREPARATION OF 4-ALKOXY-3-HYDROXYPICOLINIC ACIDS | DOW AGROSCIENCES LLC (US) | 2020-09-16 | — | — | EP | disclosed |
| EP-3166927-B1 | PROCESS FOR THE PREPARATION OF 4-ALKOXY-3-HYDROXYPICOLINIC ACIDS | DOW AGROSCIENCES LLC (US) | 2020-04-22 | — | — | EP | disclosed |
| US-10550083-B2 | Processes for the preparation of 4-alkoxy-3-hydroxypicolinic acids | DOW AGROSCIENCES LLC (US) | 2020-02-04 | — | — | US | disclosed |
| EP-3166612-B1 | PROCESS FOR THE PREPARATION OF 4-ALKOXY-3-HYDROXYPICOLINIC ACIDS | DOW AGROSCIENCES LLC (US) | 2019-06-12 | — | — | EP | disclosed |
| US-20190112271-A1 | PROCESSES FOR THE PREPARATION OF 4-ALKOXY-3-HYDROXYPICOLINIC ACIDS | CORTEVA AGRISCIENCE LLC | 2019-04-18 | — | — | US | disclosed |
| US-10259789-B2 | Process for the preparation of 4-alkoxy-3-acetoxypicolinic acids | DOW AGROSCIENCES LLC (US) | 2019-04-16 | — | — | US | disclosed |
| US-20190047962-A1 | PROCESS FOR THE PREPARATION OF 4-ALKOXY-3-ACETOXYPICOLINIC ACIDS | DOW AGROSCIENCES LLC (US) | 2019-02-14 | — | — | US | disclosed |
| EP-3405034-A1 | PROCESS FOR THE PREPARATION OF 4-ALKOXY-3-HYDROXYPICOLINIC ACIDS | Dow Agrosciences LLC (US) | 2018-11-28 | — | — | EP | disclosed |
| EP-3405456-A1 | PROCESS FOR THE PREPARATION OF 4-ALKOXY-3-ACETOXYPICOLINIC ACIDS | Dow Agrosciences LLC (US) | 2018-11-28 | — | — | EP | disclosed |
| US-20170044105-A1 | PROCESS FOR THE PREPARATION OF 4-ALKOXY-3-HYDROXYPICOLINIC ACIDS | CORTEVA AGRISCIENCE LLC | 2017-02-16 | — | — | US | disclosed |
| US-9522887-B2 | Process for the preparation of dibromohydroxypicolinonitrile | DOW AGROSCIENCES LLC (US) | 2016-12-20 | — | — | US | disclosed |
| US-9481651-B2 | Process for the preparation of 4-alkoxy-3-hydroxypicolinic acids | DOW AGROSCIENCES LLC (US) | 2016-11-01 | — | — | US | disclosed |
| US-9475771-B2 | Process for the preparation of 4-alkoxy-3-hydroxypicolinic acids | DOW AGROSCIENCES LLC (US) | 2016-10-25 | — | — | US | disclosed |
| US-20160009676-A1 | PROCESS FOR THE PREPARATION OF 4-ALKOXY-3-HYDROXYPICOLINIC ACIDS | CORTEVA AGRISCIENCE LLC | 2016-01-14 | — | — | US | disclosed |
| US-20160009649-A1 | PROCESS FOR THE PREPARATION OF 4-ALKOXY-3-HYDROXYPICOLINIC ACIDS | CORTEVA AGRISCIENCE LLC | 2016-01-14 | — | — | US | disclosed |
| WO-2016007637-A1 | PROCESS FOR THE PREPARATION OF 4-ALKOXY-3-HYDROXYPICOLINIC ACIDS | DOW AGROSCIENCES LLC (US) | 2016-01-14 | — | — | WO | disclosed |
| WO-2016007638-A1 | PROCESS FOR THE PREPARATION OF 4-ALKOXY-3-HYDROXYPICOLINIC ACIDS | DOW AGROSCIENCES LLC (US) | 2016-01-14 | — | — | WO | disclosed |
| WO-2016007634-A1 | PROCESS FOR THE PREPARATION OF 4-ALKOXY-3-HYDROXYPICOLINIC ACIDS | DOW AGROSCIENCES LLC (US) | 2016-01-14 | — | — | WO | disclosed |
| US-20160009650-A1 | PROCESS FOR THE PREPARATION OF 4-ALKOXY-3-HYDROXYPICOLINIC ACIDS | CORTEVA AGRISCIENCE LLC | 2016-01-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190047962-A1 | PROCESS FOR THE PREPARATION OF 4-ALKOXY-3-ACETOXYPICOLINIC ACIDS | HPD, HAAO, CA4 | ALOX5 797/4885KMT2A 2171/4885POLB 4116/4885 |
| US-20190112271-A1 | PROCESSES FOR THE PREPARATION OF 4-ALKOXY-3-HYDROXYPICOLINIC ACIDS | HPD, HAAO, BLVRB | ALOX5 994/4885KMT2A 2261/4885POLB 1570/4885 |
| US-20160009649-A1 | PROCESS FOR THE PREPARATION OF 4-ALKOXY-3-HYDROXYPICOLINIC ACIDS | HAAO, HPD, PAH | ALOX5 835/4885KMT2A 2528/4885POLB 1863/4885 |
| US-20160009650-A1 | PROCESS FOR THE PREPARATION OF 4-ALKOXY-3-HYDROXYPICOLINIC ACIDS | HPD, HAAO, BLVRB | ALOX5 764/4885KMT2A 2565/4885POLB 1151/4885 |
| US-10550083-B2 | Processes for the preparation of 4-alkoxy-3-hydroxypicolinic acids | HPD, HAAO, BLVRB | ALOX5 994/4885KMT2A 2261/4885POLB 1570/4885 |
| US-20170044105-A1 | PROCESS FOR THE PREPARATION OF 4-ALKOXY-3-HYDROXYPICOLINIC ACIDS | HPD, HAAO, BLVRB | ALOX5 764/4885KMT2A 2565/4885POLB 1151/4885 |
| US-10259789-B2 | Process for the preparation of 4-alkoxy-3-acetoxypicolinic acids | HPD, HAAO, CA4 | ALOX5 797/4885KMT2A 2171/4885POLB 4116/4885 |
| US-20160009676-A1 | PROCESS FOR THE PREPARATION OF 4-ALKOXY-3-HYDROXYPICOLINIC ACIDS | HPD, HAAO, BLVRB | ALOX5 764/4885KMT2A 2565/4885POLB 1151/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.