Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1879639 | 0.80 | KMT2A (0.40) | MEN1KMT2ANPC1RAB9ALMNA | |
| SCHEMBL28836041 | 0.76 | L3MBTL1 (0.55) | MEN1KMT2ANPC1RAB9ALMNA | |
| SCHEMBL23985444 | 0.76 | MEN1 (0.43) | MEN1KMT2ANPC1RAB9ALMNA | |
| SCHEMBL12273053 | 0.74 | MEN1 (0.36) | MEN1KMT2ANPC1RAB9ALMNA | |
| SCHEMBL12273055 | 0.74 | MEN1 (0.36) | MEN1KMT2ANPC1RAB9ALMNA | |
| SCHEMBL29842006 | 0.73 | KMT2A (0.41) | MEN1KMT2ANPC1RAB9ALMNA | |
| SCHEMBL6913009 | 0.72 | — | — | |
| SCHEMBL23662085 | 0.72 | MEN1 (0.38) | MEN1KMT2ANPC1RAB9ALMNA | |
| SCHEMBL28820681 | 0.72 | GAA (0.46) | MEN1KMT2ANPC1RAB9ALMNA | |
| SCHEMBL29881688 | 0.72 | GAA (0.46) | MEN1KMT2ANPC1RAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9878996-B2 | 2-imidazolyl-pyrimidine scaffolds as potent and selective inhibitors of neuronal nitric oxide synthase | NORTHWESTERN UNIVERSITY (US) | 2018-01-30 | — | — | US | disclosed |
| US-9878996-B2 | 2-imidazolyl-pyrimidine scaffolds as potent and selective inhibitors of neuronal nitric oxide synthase | NORTHWESTERN UNIVERSITY (US) | 2018-01-30 | — | — | US | disclosed |
| US-20170260165-A1 | 2-Imidazolyl-Pyrimidine Scaffolds as Potent and Selective Inhibitors of Neuronal Nitric Oxide Synthase | NORTHWESTERN UNIVERSITY (US) | 2017-09-14 | — | — | US | disclosed |
| US-20170260165-A1 | 2-Imidazolyl-Pyrimidine Scaffolds as Potent and Selective Inhibitors of Neuronal Nitric Oxide Synthase | NORTHWESTERN UNIVERSITY (US) | 2017-09-14 | — | — | US | disclosed |
| US-9701661-B2 | 2-imidazolyl-pyrimidine scaffolds as potent and selective inhibitors of neuronal nitric oxide synthase | NORTHWESTERN UNIVERSITY (US) | 2017-07-11 | — | — | US | disclosed |
| US-9701661-B2 | 2-imidazolyl-pyrimidine scaffolds as potent and selective inhibitors of neuronal nitric oxide synthase | NORTHWESTERN UNIVERSITY (US) | 2017-07-11 | — | — | US | disclosed |
| EP-3166938-A2 | 2-IMIDAZOLYL-PYRIMIDINE SCAFFOLDS AS POTENT AND SELECTIVE INHIBITORS OF NEURONAL NITRIC OXIDE SYNTHASE | Northwestern University (US) | 2017-05-17 | — | — | EP | disclosed |
| WO-2016007966-A2 | 2-IMIDAZOLYL-PYRIMIDINE SCAFFOLDS AS POTENT AND SELECTIVE INHIBITORS OF NEURONAL NITRIC OXIDE SYNTHASE | NORTHWESTERN UNIVERSITY (US) | 2016-01-14 | — | — | WO | disclosed |
| US-20160009690-A1 | 2-Imidazolyl-Pyrimidine Scaffolds as Potent and Selective Inhibitors of Neuronal Nitric Oxide Synthase | NORTHWESTERN UNIVERSITY | 2016-01-14 | — | — | US | disclosed |
| US-20160009690-A1 | 2-Imidazolyl-Pyrimidine Scaffolds as Potent and Selective Inhibitors of Neuronal Nitric Oxide Synthase | NORTHWESTERN UNIVERSITY | 2016-01-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160009690-A1 | 2-Imidazolyl-Pyrimidine Scaffolds as Potent and Selective Inhibitors of Neuronal Nitric Oxide Synthase | HMOX1, HMOX2, PPOX | MEN1 4476/4885KMT2A 2452/4885NPC1 2628/4885 |
| US-20170260165-A1 | 2-Imidazolyl-Pyrimidine Scaffolds as Potent and Selective Inhibitors of Neuronal Nitric Oxide Synthase | HMOX1, HMOX2, PPOX | MEN1 4476/4885KMT2A 2452/4885NPC1 2628/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.