Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.46 |
| ▸ | LTA4H | P09960 | 2/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.44 |
| ▸ | KDR | P35968 | 4/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | METAP2 | P50579 | 2/20 | 0.42 |
| ▸ | AXL | P30530 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.40 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | CDK4 | P11802 | 1/20 | 0.39 |
| ▸ | CCND1 | P24385 | 1/20 | 0.39 |
| ▸ | CCND3 | P30281 | 1/20 | 0.39 |
| ▸ | TTK | P33981 | 1/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13923958 | 0.84 | KDR (0.59) | LTA4HCHEK1KDRFGFR1LCK | |
| SCHEMBL26979912 | 0.82 | KDR (0.45) | CHEK1KDRFGFR1PRMT5WDR77 | |
| SCHEMBL29644267 | 0.82 | KDR (0.45) | CHEK1KDRFGFR1PRMT5WDR77 | |
| SCHEMBL17423737 | 0.79 | LMNA (0.48) | LMNATDP1CYP19A1LTA4HCHEK1 | |
| SCHEMBL17423747 | 0.78 | LMNA (0.47) | LMNATDP1CYP19A1LTA4HCHEK1 | |
| SCHEMBL17423759 | 0.76 | KDM4E (0.53) | LMNATDP1KDRFGFR1METAP2 | |
| SCHEMBL17432054 | 0.75 | LMNA (0.43) | LMNATDP1CYP19A1LTA4HCHEK1 | |
| Bromide SCHEMBL17423756 | 0.74 | LMNA (0.43) | LMNATDP1CYP19A1LTA4HCHEK1 | |
| SCHEMBL17423828 | 0.73 | METAP2 (0.42) | LMNATDP1CHEK1KDRFGFR1 | |
| SCHEMBL28967659 | 0.72 | LMNA (0.57) | LMNATDP1CYP19A1LTA4HMETAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016007837-A1 | CARBONYL LINKED BICYCLIC HETEROARYL ANTIBIOTIC TOLERANCE INHIBITORS | SPERO THERAPEUTICS, INC. (US) | 2016-01-14 | — | — | WO | disclosed |
| WO-2016007837-A1 | CARBONYL LINKED BICYCLIC HETEROARYL ANTIBIOTIC TOLERANCE INHIBITORS | SPERO THERAPEUTICS, INC. (US) | 2016-01-14 | — | — | WO | disclosed |