Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | EGLN2 | Q96KS0 | 2/20 | 0.44 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.44 |
| ▸ | METAP2 | P50579 | 1/20 | 0.44 |
| ▸ | PRKAG1 | P54619 | 4/20 | 0.43 |
| ▸ | PRKAA1 | Q13131 | 4/20 | 0.43 |
| ▸ | PRKAB1 | Q9Y478 | 4/20 | 0.43 |
| ▸ | KDR | P35968 | 4/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.43 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | PRKAB2 | O43741 | 3/20 | 0.42 |
| ▸ | PRKAA2 | P54646 | 3/20 | 0.42 |
| ▸ | PRKAG3 | Q9UGI9 | 3/20 | 0.42 |
| ▸ | PRKAG2 | Q9UGJ0 | 3/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.42 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17423747 | 0.89 | LMNA (0.47) | LMNATDP1EGLN2EGLN1METAP2 | |
| SCHEMBL17423759 | 0.87 | KDM4E (0.53) | LMNATDP1EGLN2EGLN1METAP2 | |
| SCHEMBL17432054 | 0.86 | LMNA (0.43) | LMNATDP1EGLN2EGLN1METAP2 | |
| Bromide SCHEMBL17423756 | 0.85 | LMNA (0.43) | LMNATDP1EGLN2EGLN1METAP2 | |
| SCHEMBL26980051 | 0.84 | PRKAG1 (0.47) | PRKAG1PRKAA1PRKAB1KDRCHEK1 | |
| SCHEMBL29644268 | 0.84 | PRKAG1 (0.47) | PRKAG1PRKAA1PRKAB1KDRCHEK1 | |
| SCHEMBL17423828 | 0.83 | METAP2 (0.42) | LMNATDP1EGLN2EGLN1METAP2 | |
| SCHEMBL17423781 | 0.79 | LMNA (0.53) | LMNATDP1METAP2KDRCHEK1 | |
| SCHEMBL176882 | 0.76 | PRKAG1 (0.66) | TDP1PRKAG1PRKAA1PRKAB1PRKAB2 | |
| SCHEMBL17597511 | 0.74 | DRD2 (0.38) | TDP1EGLN2EGLN1METAP2DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016007837-A1 | CARBONYL LINKED BICYCLIC HETEROARYL ANTIBIOTIC TOLERANCE INHIBITORS | SPERO THERAPEUTICS, INC. (US) | 2016-01-14 | — | — | WO | disclosed |
| WO-2016007837-A1 | CARBONYL LINKED BICYCLIC HETEROARYL ANTIBIOTIC TOLERANCE INHIBITORS | SPERO THERAPEUTICS, INC. (US) | 2016-01-14 | — | — | WO | disclosed |