Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | LIG1 | P18858 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CTSD | P07339 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | STAT3 | P40763 | 1/20 | 0.34 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL668137 | 0.85 | HTT (0.44) | KDM4ESMN1; SMN2HTTMEN1KMT2A | |
| SCHEMBL10139047 | 0.85 | SMN1; SMN2 (0.43) | KDM4ESMN1; SMN2HTTMEN1KMT2A | |
| SCHEMBL668685 | 0.84 | MAPT (0.45) | KDM4ESMN1; SMN2HTTMEN1KMT2A | |
| SCHEMBL10139038 | 0.83 | CYP3A4 (0.55) | KDM4ESMN1; SMN2HTTMEN1KMT2A | |
| SCHEMBL14703579 | 0.79 | CYP3A4 (0.38) | KDM4ESMN1; SMN2HTTMEN1KMT2A | |
| SCHEMBL667972 | 0.78 | RAB9A (0.38) | KDM4ESMN1; SMN2HTTMEN1KMT2A | |
| SCHEMBL668599 | 0.78 | LMNA (0.40) | KDM4ESMN1; SMN2HTTMEN1KMT2A | |
| SCHEMBL4684488 | 0.70 | SMN1; SMN2 (0.41) | KDM4ESMN1; SMN2HTTKMT2APOLB | |
| SCHEMBL4683233 | 0.69 | CTSD (0.39) | KDM4ESMN1; SMN2HTTMEN1KMT2A | |
| SCHEMBL28663786 | 0.69 | KDM4E (0.42) | KDM4ESMN1; SMN2HTTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2463269-B1 | Bioavailable diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex | INTREXON CORP (US) | 2016-09-28 | — | — | EP | disclosed |
| EP-2460786-B1 | Bioavailable diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex | INTREXON CORP (US) | 2016-01-13 | — | — | EP | disclosed |