Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | NT5E | P21589 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2552834 | 0.87 | GABRP (0.50) | IKBKBALDH1A1KDM4ESMN1; SMN2MEN1 | |
| SCHEMBL17339728 | 0.85 | IKBKB (0.45) | IKBKBALDH1A1KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL19841045 | 0.84 | TLR8 (0.49) | IKBKBALDH1A1KDM4ESMN1; SMN2NPC1 | |
| SCHEMBL9632112 | 0.83 | RAB9A (0.52) | IKBKBALDH1A1KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL11431563 | 0.81 | IKBKB (0.42) | IKBKBALDH1A1KDM4ESMN1; SMN2MEN1 | |
| SCHEMBL28559696 | 0.80 | SMN1; SMN2 (0.41) | IKBKBALDH1A1KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL27828993 | 0.77 | IKBKB (0.50) | IKBKBALDH1A1KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL7915323 | 0.77 | SMN1; SMN2 (0.59) | IKBKBALDH1A1KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL12014829 | 0.77 | PSMB5 (0.62) | ALDH1A1KDM4EMAPTMEN1KMT2A | |
| SCHEMBL22279055 | 0.77 | RXFP1 (0.47) | IKBKBALDH1A1KDM4EMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3138831-A1 | SYNTHESIS OF TETRACYCLINES AND ANALOGUES THEREOF | President and Fellows of Harvard College (US) | 2017-03-08 | — | — | EP | disclosed |
| US-20160340325-A1 | SYNTHESIS OF TETRACYCLINES AND ANALOGUES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2016-11-24 | — | — | US | disclosed |
| US-20160009652-A1 | SMALL-MOLECULE MODULATORS OF MELANIN EXPRESSION | UNIV ROCHESTER (US) | 2016-01-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160009652-A1 | SMALL-MOLECULE MODULATORS OF MELANIN EXPRESSION | TYR, MITF, MC1R | IKBKB 3321/4885ALDH1A1 737/4885KDM4E 3027/4885 |
| US-20160340325-A1 | SYNTHESIS OF TETRACYCLINES AND ANALOGUES THEREOF | TET1, TET3, MYC | IKBKB 571/4885ALDH1A1 4455/4885KDM4E 800/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.