Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR4 | O95977 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 5/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | TTR | P02766 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20855342 | 0.86 | S1PR4 (0.73) | S1PR4LMNAMAPTALDH1A1MAPK1 | |
| SCHEMBL29485957 | 0.83 | LMNA (0.59) | S1PR4LMNAMAPTALDH1A1MAPK1 | |
| SCHEMBL1119379 | 0.83 | LMNA (0.59) | S1PR4LMNAMAPTALDH1A1MAPK1 | |
| SCHEMBL10387432 | 0.83 | PDE7A (0.71) | S1PR4LMNAMAPTALDH1A1MAPK1 | |
| SCHEMBL3149944 | 0.82 | L3MBTL1 (0.72) | LMNAMAPTALDH1A1SMN1; SMN2TTR | |
| SCHEMBL3654191 | 0.81 | PDE7A (0.63) | S1PR4LMNAMAPTALDH1A1MAPK1 | |
| SCHEMBL9687621 | 0.80 | TSHR (0.64) | S1PR4LMNAMAPTALDH1A1MAPK1 | |
| SCHEMBL12850975 | 0.79 | TTR (0.67) | LMNAMAPTALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL317536 | 0.78 | ALDH1A1 (0.66) | S1PR4LMNAMAPTALDH1A1MAPK1 | |
| SCHEMBL18184327 | 0.78 | S1PR4 (0.56) | S1PR4LMNAMAPTALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016007534-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2016-01-14 | — | — | WO | disclosed |