Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.59 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 4/20 | 0.55 |
| ▸ | NPC1 | O15118 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | MAOA | P21397 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10913233 | 0.87 | SMN1; SMN2 (0.66) | SMN1; SMN2RAB9ANPC1POLBMEN1 | |
| SCHEMBL12046068 | 0.87 | RAB9A (0.54) | SMN1; SMN2RAB9ANPC1POLBLMNA | |
| SCHEMBL10911188 | 0.87 | L3MBTL1 (0.58) | SMN1; SMN2RAB9ANPC1POLBLMNA | |
| SCHEMBL11338235 | 0.84 | SMN1; SMN2 (0.70) | SMN1; SMN2GAARAB9ANPC1POLB | |
| SCHEMBL12046080 | 0.84 | ALDH1A1 (0.57) | SMN1; SMN2RAB9ANPC1POLBLMNA | |
| SCHEMBL10910981 | 0.84 | KMT2A (0.71) | SMN1; SMN2RAB9ANPC1MEN1ALDH1A1 | |
| SCHEMBL12046038 | 0.83 | SMN1; SMN2 (0.59) | SMN1; SMN2GAARAB9ANPC1POLB | |
| SCHEMBL18050209 | 0.82 | SMN1; SMN2 (0.67) | SMN1; SMN2GAARAB9ANPC1POLB | |
| SCHEMBL9859901 | 0.82 | SMN1; SMN2 (0.67) | SMN1; SMN2RAB9ANPC1LMNAMEN1 | |
| SCHEMBL166484 | 0.79 | LMNA (0.82) | SMN1; SMN2GAARAB9ANPC1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8871944-B2 | Thiazole derivative and process for producing same | GIFU UNIVERSITY (JP) | 2014-10-28 | — | — | US | claimed |
| EP-2389361-B1 | TECHNETIUM- AND RHENIUM-BIS(HETEROARYL) COMPLEXES AND METHODS OF USE THEREOF FOR INHIBITING PSMA | MOLECULAR INSIGHT PHARM INC (US) | 2016-08-24 | — | — | EP | disclosed |
| EP-2388253-B1 | THIAZOLE DERIVATIVE AND PROCESS FOR PRODUCING SAME | UNIV GIFU (JP) | 2015-02-11 | — | — | EP | disclosed |
| EP-2388253-B1 | THIAZOLE DERIVATIVE AND PROCESS FOR PRODUCING SAME | UNIV GIFU (JP) | 2015-02-11 | — | — | EP | disclosed |
| US-8871944-B2 | Thiazole derivative and process for producing same | GIFU UNIVERSITY (JP) | 2014-10-28 | — | — | US | disclosed |
| US-8871944-B2 | Thiazole derivative and process for producing same | GIFU UNIVERSITY (JP) | 2014-10-28 | — | — | US | disclosed |
| US-8871944-B2 | Thiazole derivative and process for producing same | GIFU UNIVERSITY (JP) | 2014-10-28 | — | — | US | disclosed |
| US-20110319616-A1 | THIAZOLE DERIVATIVE AND PROCESS FOR PRODUCING SAME | GIFU UNIVERSITY (JP) | 2011-12-29 | — | — | US | disclosed |
| US-20110319616-A1 | THIAZOLE DERIVATIVE AND PROCESS FOR PRODUCING SAME | GIFU UNIVERSITY (JP) | 2011-12-29 | — | — | US | disclosed |
| EP-2388253-A1 | THIAZOLE DERIVATIVE AND PROCESS FOR PRODUCING SAME | Gifu University (JP) | 2011-11-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110319616-A1 | THIAZOLE DERIVATIVE AND PROCESS FOR PRODUCING SAME | TST, TALDO1, TBCD | SMN1; SMN2 4468/4885GAA 526/4885RAB9A 3873/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.