Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MBOAT4 | Q96T53 | 1/20 | 0.47 |
| ▸ | BRD4 | O60885 | 2/20 | 0.41 |
| ▸ | KDM4A | O75164 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | CCR1 | P32246 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31098603 | 1.00 | MBOAT4 (0.47) | MBOAT4BRD4KDM4ANPSR1CYP1A2 | |
| SCHEMBL18517164 | 0.86 | MBOAT4 (0.47) | MBOAT4BRD4KDM4ANPSR1CYP1A2 | |
| SCHEMBL28923327 | 0.85 | TRPM8 (0.40) | MBOAT4BRD4NPSR1CYP1A2TDP1 | |
| SCHEMBL23982353 | 0.84 | MBOAT4 (0.49) | MBOAT4BRD4KDM4ANPSR1CYP1A2 | |
| SCHEMBL1742260 | 0.84 | MBOAT4 (0.46) | MBOAT4BRD4KDM4ANPSR1CYP1A2 | |
| SCHEMBL17819497 | 0.83 | TRPM8 (0.37) | MBOAT4BRD4NPSR1CYP1A2MRGPRX4 | |
| SCHEMBL29289937 | 0.83 | BRD4 (0.40) | MBOAT4BRD4NPSR1CYP1A2 | |
| Hydrochloric Acid SCHEMBL31098552 | 0.83 | MBOAT4 (0.48) | MBOAT4BRD4KDM4ANPSR1CYP1A2 | |
| SCHEMBL18157885 | 0.82 | TDP1 (0.52) | MBOAT4KDM4ACYP1A2TDP1KDM4E | |
| SCHEMBL29289870 | 0.82 | PARP1 (0.39) | MBOAT4BRD4MEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2387573-B1 | 6-PHENYL-1H-IMIDAZO[4,5-C]PYRIDINE-4-CARBONITRILE DERIVATIVES AS CATHEPSIN S AND/OR CATHEPSIN K INHIBITORS | ORGANON BIOSCIENCES NEDERLAND B V (NL) | 2013-07-31 | — | — | EP | disclosed |
| EP-2387573-B1 | 6-PHENYL-1H-IMIDAZO[4,5-C]PYRIDINE-4-CARBONITRILE DERIVATIVES AS CATHEPSIN S AND/OR CATHEPSIN K INHIBITORS | ORGANON BIOSCIENCES NEDERLAND B V (NL) | 2013-07-31 | — | — | EP | disclosed |
| EP-2387573-A1 | 6-PHENYL-LH-IMIDAZO Ý4, 5-C¨PYRIDINE-4-CARBONITRILE DERIVATIVES AS CATHEPSIN S AND/OR CATHEPSIN K INHIBITORS | N.V. Organon (NL) | 2011-11-23 | — | — | EP | disclosed |
| US-20110253004-A1 | RAILCAR PRIMARY SUSPENSION | KAWASAKI JUKOGYO KABUSHIKI KAISHA (JP) | 2011-10-20 | — | — | US | disclosed |
| US-8026236-B2 | 6-phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivatives | N.V. ORGANON (NL) | 2011-09-27 | — | — | US | disclosed |
| US-8026236-B2 | 6-phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivatives | N.V. ORGANON (NL) | 2011-09-27 | — | — | US | disclosed |
| US-8026236-B2 | 6-phenyl-1H-imidazo[4,5-c]pyridine-4-carbonitrile derivatives | N.V. ORGANON (NL) | 2011-09-27 | — | — | US | disclosed |
| US-20100184761-A1 | 6-PHENYL-1H-IMIDAZO[4,5-c]PYRIDINE-4-CARBONITRILE DERIVATIVES | N.V. ORGANON | 2010-07-22 | — | — | US | disclosed |
| US-20100184761-A1 | 6-PHENYL-1H-IMIDAZO[4,5-c]PYRIDINE-4-CARBONITRILE DERIVATIVES | N.V. ORGANON | 2010-07-22 | — | — | US | disclosed |
| US-20100184761-A1 | 6-PHENYL-1H-IMIDAZO[4,5-c]PYRIDINE-4-CARBONITRILE DERIVATIVES | N.V. ORGANON | 2010-07-22 | — | — | US | disclosed |
| WO-2010081859-A1 | 6-PHENYL-LH-IMIDAZO [4, 5-C] PYRIDINE-4-CARBONITRILE DERIVATIVES AS CATHEPSIN S AND/OR CATHEPSIN K INHIBITORS | N.V. ORGANON (NL) | 2010-07-22 | — | — | WO | disclosed |
| WO-2010081859-A1 | 6-PHENYL-LH-IMIDAZO [4, 5-C] PYRIDINE-4-CARBONITRILE DERIVATIVES AS CATHEPSIN S AND/OR CATHEPSIN K INHIBITORS | N.V. ORGANON (NL) | 2010-07-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100184761-A1 | 6-PHENYL-1H-IMIDAZO[4,5-c]PYRIDINE-4-CARBONITRILE DERIVATIVES | CTSS, CTSV, CTSB | MBOAT4 4266/4885BRD4 1491/4885KDM4A 2188/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.