Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 4/20 | 0.33 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | RAD52 | P43351 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Isoquinoline SCHEMBL29501078 | 1.00 | TNF (0.37) | TNFKDM4ECYP3A4CYP2C9CYP2C19 | |
| Naphthalene SCHEMBL303703 | 0.88 | CYP2A6 (0.40) | EGFRCYP17A1CYP19A1CYP11B1CYP11B2 | |
| Isoquinoline SCHEMBL27756923 | 0.87 | ALDH1A1 (0.50) | KDM4ECYP3A4CYP2C19CYP1A2EGFR | |
| Isoquinoline SCHEMBL28313825 | 0.82 | TNF (0.40) | TNFKDM4ECYP3A4CYP2C9CYP2C19 | |
| Isoquinoline SCHEMBL30286035 | 0.81 | TNF (0.48) | TNFKDM4ECYP3A4CYP2C9CYP2C19 | |
| Isoquinoline SCHEMBL29355164 | 0.81 | TNF (0.48) | TNFKDM4ECYP3A4CYP2C9CYP2C19 | |
| Isoquinoline SCHEMBL31588723 | 0.81 | TNF (0.48) | TNFKDM4ECYP3A4CYP2C9CYP2C19 | |
| Naphthalene SCHEMBL7327012 | 0.81 | TNF (0.48) | TNFKDM4ECYP3A4CYP2C9CYP2C19 | |
| Isoquinoline SCHEMBL9654 | 0.81 | TNF (0.48) | TNFKDM4ECYP3A4CYP2C9CYP2C19 | |
| Isoquinoline SCHEMBL1536317 | 0.81 | TNF (0.48) | TNFKDM4ECYP3A4CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114380848-B | Preparation and application of isoquinoline thiazole salt and derivatives thereof | 华南农业大学 | 2023-03-14 | — | — | CN | claimed |
| CN-114380848-A | Preparation and application of isoquinoline thiazole salt and derivatives thereof | 华南农业大学 | 2022-04-22 | — | — | CN | claimed |
| CN-114409602-B | Method for synthesizing alpha-keto acid by using oxalyl chloride and Grignard reagent as raw materials | 武汉大学 | 2024-01-30 | — | — | CN | disclosed |
| CN-114380848-B | Preparation and application of isoquinoline thiazole salt and derivatives thereof | 华南农业大学 | 2023-03-14 | — | — | CN | disclosed |
| CN-114380848-B | Preparation and application of isoquinoline thiazole salt and derivatives thereof | 华南农业大学 | 2023-03-14 | — | — | CN | disclosed |
| CN-114380848-B | Preparation and application of isoquinoline thiazole salt and derivatives thereof | 华南农业大学 | 2023-03-14 | — | — | CN | disclosed |
| CN-114409602-A | Method for synthesizing alpha-keto acid by using oxalyl chloride and Grignard reagent as raw materials | 武汉大学 | 2022-04-29 | — | — | CN | disclosed |
| CN-114380848-A | Preparation and application of isoquinoline thiazole salt and derivatives thereof | 华南农业大学 | 2022-04-22 | — | — | CN | disclosed |
| CN-114380848-A | Preparation and application of isoquinoline thiazole salt and derivatives thereof | 华南农业大学 | 2022-04-22 | — | — | CN | disclosed |
| CN-114380848-A | Preparation and application of isoquinoline thiazole salt and derivatives thereof | 华南农业大学 | 2022-04-22 | — | — | CN | disclosed |
| EP-2387570-A1 | FLUOROISOQUINOLINE SUBSTITUTED THIAZOLE COMPOUNDS AND METHODS OF USE | Amgen, Inc (US) | 2011-11-23 | — | — | EP | disclosed |
| US-20110263647-A1 | FLUOROISOQUINOLINE SUBSTITUTED THIAZOLE COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2011-10-27 | — | — | US | disclosed |
| CN-101657583-B | Fractionation of a lignocellulosic material | UNIV QUEENSLAND | 2011-09-28 | — | — | CN | disclosed |
| WO-2010083246-A1 | FLUOROISOQUINOLINE SUBSTITUTED THIAZOLE COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2010-07-22 | — | — | WO | disclosed |
| CN-101657583-A | Fractionation of a lignocellulosic material | UNIV QUEENSLAND AU | 2010-02-24 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110263647-A1 | FLUOROISOQUINOLINE SUBSTITUTED THIAZOLE COMPOUNDS AND METHODS OF USE | TFEB, PCK2, JAK2 | TNF 786/4885KDM4E 3719/4885CYP3A4 2741/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.