Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 5/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | NAAA | Q02083 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | PREP | P48147 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19176761 | 0.95 | ALDH1A1 (0.59) | ALDH1A1SMN1; SMN2MAPTMAPK1LMNA | |
| SCHEMBL19169581 | 0.82 | ALDH1A1 (0.55) | ALDH1A1SMN1; SMN2MAPTMAPK1LMNA | |
| SCHEMBL19176798 | 0.74 | SMN1; SMN2 (0.48) | ALDH1A1SMN1; SMN2LMNAL3MBTL1KDM4E | |
| SCHEMBL13577958 | 0.74 | ALDH1A1 (0.82) | ALDH1A1SMN1; SMN2MAPTLMNAL3MBTL1 | |
| SCHEMBL20152038 | 0.72 | L3MBTL1 (0.50) | ALDH1A1SMN1; SMN2MAPTMAPK1LMNA | |
| SCHEMBL11622449 | 0.72 | GAA (0.64) | ALDH1A1SMN1; SMN2L3MBTL1KDM4EHPGD | |
| SCHEMBL12895167 | 0.71 | NAAA (0.51) | ALDH1A1SMN1; SMN2LMNAL3MBTL1KDM4E | |
| SCHEMBL21045484 | 0.70 | ALDH1A1 (0.51) | ALDH1A1SMN1; SMN2MAPTMAPK1LMNA | |
| SCHEMBL11365087 | 0.70 | KMT2A (0.54) | ALDH1A1SMN1; SMN2MAPTMAPK1LMNA | |
| SCHEMBL18896237 | 0.70 | NAAA (0.54) | ALDH1A1SMN1; SMN2LMNAL3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016008582-A1 | SUBSTITUTED AZASPIRO(4.5)DECANE DERIVATIVES | Grünenthal GmbH (DE) | 2016-01-21 | — | — | WO | disclosed |