Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | NAAA | Q02083 | 4/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 4/20 | 0.43 |
| ▸ | MLYCD | O95822 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17447469 | 0.94 | ALDH1A1 (0.47) | L3MBTL1ALDH1A1KDM4ELMNASMN1; SMN2 | |
| SCHEMBL13577958 | 0.73 | ALDH1A1 (0.82) | L3MBTL1ALDH1A1KDM4ELMNASMN1; SMN2 | |
| SCHEMBL17447459 | 0.72 | ALDH1A1 (0.58) | L3MBTL1ALDH1A1KDM4ELMNASMN1; SMN2 | |
| SCHEMBL18896240 | 0.72 | POLB (0.77) | L3MBTL1ALDH1A1KDM4ELMNASMN1; SMN2 | |
| SCHEMBL20152042 | 0.72 | POLB (0.77) | L3MBTL1ALDH1A1KDM4ELMNASMN1; SMN2 | |
| SCHEMBL23430581 | 0.72 | KEAP1 (0.61) | L3MBTL1ALDH1A1KDM4ELMNASMN1; SMN2 | |
| SCHEMBL31467551 | 0.69 | EPHX1 (0.64) | L3MBTL1ALDH1A1LMNASMN1; SMN2NAAA | |
| SCHEMBL18896237 | 0.69 | NAAA (0.54) | L3MBTL1ALDH1A1KDM4ELMNASMN1; SMN2 | |
| SCHEMBL9504178 | 0.69 | L3MBTL1 (0.86) | L3MBTL1ALDH1A1SMN1; SMN2NAAAMAPT | |
| SCHEMBL6437809 | 0.69 | NAAA (0.71) | L3MBTL1ALDH1A1SMN1; SMN2NAAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10369140-B2 | Aryl dihydropyridinones and piperidinone MGAT2 inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2019-08-06 | — | — | US | disclosed |
| US-20180133198-A1 | ARYL DIHYDROPYRIDINONES AND PIPERIDINONE MGAT2 INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2018-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180133198-A1 | ARYL DIHYDROPYRIDINONES AND PIPERIDINONE MGAT2 INHIBITORS | DGAT2, MGAT2, MGAT1 | L3MBTL1 3591/4885ALDH1A1 284/4885KDM4E 1993/4885 |
| US-10369140-B2 | Aryl dihydropyridinones and piperidinone MGAT2 inhibitors | DGAT2, MGAT2, MGAT1 | L3MBTL1 3591/4885ALDH1A1 284/4885KDM4E 1993/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.