Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 1/20 | 0.55 |
| ▸ | CALCR | P30988 | 4/20 | 0.52 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.52 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.52 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.51 |
| ▸ | F2 | P00734 | 3/20 | 0.49 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.49 |
| ▸ | NPY2R | P49146 | 6/20 | 0.49 |
| ▸ | NPY4R | P50391 | 6/20 | 0.49 |
| ▸ | NPY5R | Q15761 | 6/20 | 0.49 |
| ▸ | NPY1R | P25929 | 4/20 | 0.49 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.49 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.48 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.48 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17451637 | 0.94 | APLNR (0.50) | APLNRCALCRHCRTR1HCRTR2CXCR4 | |
| SCHEMBL17451633 | 0.94 | APLNR (0.52) | APLNRCALCRHCRTR1HCRTR2CXCR4 | |
| SCHEMBL17451638 | 0.93 | APLNR (0.52) | APLNRCALCRHCRTR1HCRTR2CXCR4 | |
| SCHEMBL29706466 | 0.90 | MAPK8 (0.58) | APLNRCALCRCXCR4NPY2RNPY4R | |
| SCHEMBL30688070 | 0.88 | MAPK8 (0.60) | APLNRCALCRCXCR4F2NPY2R | |
| SCHEMBL31691539 | 0.87 | APLNR (0.61) | APLNRCALCRCXCR4F2SLC40A1 | |
| SCHEMBL29767745 | 0.86 | CALCR (0.63) | APLNRCALCRHCRTR1HCRTR2CXCR4 | |
| SCHEMBL30008485 | 0.86 | CALCR (0.62) | APLNRCALCRHCRTR1HCRTR2CXCR4 | |
| SCHEMBL30688082 | 0.85 | EPHA2 (0.59) | CALCRNPY2RNPY4RNPY5RNPY1R | |
| SCHEMBL31691514 | 0.85 | APLNR (0.62) | APLNRCALCRHCRTR1HCRTR2CXCR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160016998-A1 | HIGH-AFFINITY MATRIPTASE INHIBITORS | MERCK PATENT GMBH (DE) | 2016-01-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160016998-A1 | HIGH-AFFINITY MATRIPTASE INHIBITORS | MMP7, MATR3, TMPRSS15 | APLNR 182/4885CALCR 3150/4885HCRTR1 3828/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.