Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 2/20 | 0.48 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | DPP4 | P27487 | 2/20 | 0.41 |
| ▸ | FAP | Q12884 | 1/20 | 0.41 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.41 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.41 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CCNC | P24863 | 6/20 | 0.40 |
| ▸ | CDK8 | P49336 | 6/20 | 0.40 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.40 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.40 |
| ▸ | TRPC6 | Q9Y210 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17453076 | 0.87 | CCNC (0.49) | RIPK1ROCK2HSD17B10CCNCCDK8 | |
| SCHEMBL17453078 | 0.87 | RIPK1 (0.47) | RIPK1HSD17B10DPP4FAPDPP8 | |
| SCHEMBL17453070 | 0.87 | HSD11B1 (0.51) | RIPK1ROCK2CCNCCDK8ADAM17 | |
| SCHEMBL17453077 | 0.86 | RIPK1 (0.64) | RIPK1ADAM17HSP90AA1HSP90AB1 | |
| SCHEMBL14252999 | 0.86 | RIPK1 (0.64) | RIPK1ADAM17HSP90AA1HSP90AB1 | |
| SCHEMBL25310761 | 0.85 | DPP4 (0.43) | RIPK1AGTR2ROCK2HSD17B10DPP4 | |
| SCHEMBL17142323 | 0.83 | RIPK1 (0.55) | RIPK1AGTR2ROCK2HSD17B10NPC1 | |
| SCHEMBL24133882 | 0.82 | RIPK1 (0.41) | RIPK1AGTR2ROCK2HSD17B10NPC1 | |
| SCHEMBL21425146 | 0.81 | RIPK1 (0.50) | RIPK1AGTR2ROCK2HSD17B10NPC1 | |
| SCHEMBL11457784 | 0.78 | RIPK1 (0.39) | RIPK1HSD17B10ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160016951-A1 | NOVEL NAPHTHYRIDINES AND ISOQUINOLINES AND THEIR USE AS CDK8/19 INHIBITORS | MERCK PATENT GMBH (DE) | 2016-01-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160016951-A1 | NOVEL NAPHTHYRIDINES AND ISOQUINOLINES AND THEIR USE AS CDK8/19 INHIBITORS | CDK8, CDK9, CDK18 | RIPK1 1591/4885AGTR2 2469/4885ROCK2 1068/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.