Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 4/20 | 0.64 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.52 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.52 |
| ▸ | ADAM17 | P78536 | 5/20 | 0.52 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.51 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.51 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.51 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.51 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.50 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.50 |
| ▸ | BCHE | P06276 | 1/20 | 0.49 |
| ▸ | SCD5 | Q86SK9 | 3/20 | 0.49 |
| ▸ | SCD | O00767 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14252999 | 1.00 | RIPK1 (0.64) | RIPK1HSP90AA1HSP90AB1ADAM17CHRNB2 | |
| SCHEMBL26763796 | 0.90 | RIPK1 (0.62) | RIPK1HSP90AA1HSP90AB1ADAM17CHRNB2 | |
| SCHEMBL28873931 | 0.87 | RIPK1 (0.59) | RIPK1HSP90AA1HSP90AB1ADAM17CHRNB2 | |
| SCHEMBL28873927 | 0.87 | RIPK1 (0.59) | RIPK1HSP90AA1HSP90AB1ADAM17CHRNB2 | |
| SCHEMBL17453074 | 0.86 | RIPK1 (0.48) | RIPK1HSP90AA1HSP90AB1ADAM17 | |
| SCHEMBL17453078 | 0.85 | RIPK1 (0.47) | RIPK1HSP90AA1HSP90AB1ADAM17BCHE | |
| SCHEMBL17453076 | 0.85 | CCNC (0.49) | RIPK1ADAM17SCD5 | |
| SCHEMBL17453070 | 0.85 | HSD11B1 (0.51) | RIPK1ADAM17HSD11B1 | |
| SCHEMBL27460000 | 0.84 | RIPK1 (0.56) | RIPK1HSP90AA1HSP90AB1ADAM17HSD11B1 | |
| SCHEMBL17454944 | 0.82 | RIPK1 (0.69) | RIPK1HSP90AA1HSP90AB1CHRNB2CHRNB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160016951-A1 | NOVEL NAPHTHYRIDINES AND ISOQUINOLINES AND THEIR USE AS CDK8/19 INHIBITORS | MERCK PATENT GMBH (DE) | 2016-01-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160016951-A1 | NOVEL NAPHTHYRIDINES AND ISOQUINOLINES AND THEIR USE AS CDK8/19 INHIBITORS | CDK8, CDK9, CDK18 | RIPK1 1591/4885HSP90AA1 2834/4885HSP90AB1 2368/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.