Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 3/20 | 0.54 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.47 |
| ▸ | ALKBH1 | Q13686 | 4/20 | 0.46 |
| ▸ | EPHB3 | P54753 | 1/20 | 0.46 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.44 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17437917 | 0.91 | ALKBH1 (0.53) | MAOBP4HTMALKBH1EPHB3SRD5A2 | |
| SCHEMBL1324201 | 0.89 | EPHB3 (0.46) | MAOBP4HTMALKBH1EPHB3SRD5A2 | |
| SCHEMBL19902366 | 0.89 | MAPT (0.46) | MAOBP4HTMALKBH1EPHB3SRD5A2 | |
| SCHEMBL17452634 | 0.88 | ALKBH1 (0.43) | MAOBP4HTMALKBH1EPHB3SRD5A2 | |
| SCHEMBL3611334 | 0.82 | EPHB3 (0.66) | MAOBALKBH1EPHB3SRD5A2NR4A2 | |
| SCHEMBL17454476 | 0.79 | LMNA (0.49) | EPHB3SMN1; SMN2ALDH1A1HTTMAPT | |
| SCHEMBL31416740 | 0.79 | RAB9A (0.43) | MAOBP4HTMALKBH1SMN1; SMN2L3MBTL1 | |
| SCHEMBL17454506 | 0.78 | ROCK2 (0.48) | EPHB3SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL17324670 | 0.78 | ROCK2 (0.47) | — | |
| SCHEMBL17323234 | 0.78 | LCK (0.46) | EPHB3SMN1; SMN2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160016914-A1 | SPIROCYCLOHEPTANES AS INHIBITORS OF ROCK | BRISTOL-MYERS SQUIBB COMPANY | 2016-01-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160016914-A1 | SPIROCYCLOHEPTANES AS INHIBITORS OF ROCK | ROCK1, MYLK, ROCK2 | MAOB 2525/4885P4HTM 3285/4885ALKBH1 3389/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.