SCHEMBL1745631

SCHEMBL1745631

c1ccc(Oc2cccc(COc3ccc(CCc4nnn[nH]4)cc3)c2)cc1

nearest known ligand 0.57

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ FFAR1 O14842 13/20 0.57
▸ FFAR4 Q5NUL3 4/20 0.57
▸ LTA4H P09960 2/20 0.43
▸ PLA2G2A P14555 2/20 0.43
▸ MAOB P27338 3/20 0.43
▸ AKR1B1 P15121 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14021849 0.84 RAB9A (0.50) LTA4HPLA2G2AMAOB
SCHEMBL12396411 0.82 FFAR1 (0.58) FFAR1FFAR4
SCHEMBL14021492 0.79 CYP4F2 (0.47) FFAR1MAOB
SCHEMBL14021848 0.78 CYP4F2 (0.52) FFAR1MAOB
SCHEMBL1744516 0.76 FFAR1 (0.57) FFAR1FFAR4LTA4HPLA2G2AMAOB
SCHEMBL4715479 0.76 DAO (0.47) MAOB
SCHEMBL14021516 0.76 LTA4H (0.46) LTA4HMAOB
SCHEMBL9491438 0.76 FFAR1 (0.68) FFAR1FFAR4MAOB
SCHEMBL3886612 0.76 BCHE (0.49) MAOB
SCHEMBL7717087 0.75 CYSLTR1 (0.60) —

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1559422-B1 RECEPTOR FUNCTION CONTROLLING AGENT TAKEDA PHARMACEUTICAL (JP) 2014-04-30 — — EP disclosed
EP-2385032-A1 GPR40 Receptor function regulator Takeda Pharmaceutical Company Limited (JP) 2011-11-09 — — EP disclosed
US-7960369-B2 Receptor function regulator TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2011-06-14 — — US disclosed
US-20090012093-A1 Receptor Function Regulator TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2009-01-08 — — US disclosed
EP-1559422-A1 RECEPTOR FUNCTION CONTROLLING AGENT Takeda Pharmaceutical Company Limited (JP) 2005-08-03 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090012093-A1 Receptor Function Regulator GPR119, GIPR, INSR FFAR1 33/4885FFAR4 44/4885LTA4H 1978/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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