Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.50 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.50 |
| ▸ | DAO | P14920 | 1/20 | 0.49 |
| ▸ | CNOT7 | Q9UIV1 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | HRH1 | P35367 | 1/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17457945 | 0.83 | ALDH1A1 (0.53) | HSD17B10HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL29727903 | 0.80 | CYP1A2 (0.49) | HSD17B10HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL27494735 | 0.77 | HSD17B10 (0.54) | HSD17B10DAOL3MBTL1HRH1ALDH1A1 | |
| SCHEMBL9752595 | 0.75 | L3MBTL1 (0.55) | L3MBTL1 | |
| SCHEMBL6638412 | 0.73 | HRH1 (0.50) | HSD17B10HTTHDAC3HDAC4HDAC1 | |
| SCHEMBL19669743 | 0.73 | HSD17B10 (0.47) | HSD17B10HTTHDAC3HDAC4HDAC1 | |
| SCHEMBL10417628 | 0.73 | ALDH1A1 (0.50) | HSD17B10HRH1ALDH1A1KMT2AHRH3 | |
| SCHEMBL5077099 | 0.73 | PARP1 (0.55) | HSD17B10HTTHDAC3HDAC4HDAC1 | |
| SCHEMBL17457918 | 0.73 | PSMB1 (0.55) | HSD17B10HTTHDAC6DAOL3MBTL1 | |
| SCHEMBL16026529 | 0.73 | THRB (0.61) | HSD17B10HRH1ADRA1DADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190142813-A1 | MULTISUBSTITUTED AROMATIC COMPOUNDS AS SERINE PROTEASE INHIBITORS | VERSEON INTERNATIONAL CORPORATION | 2019-05-16 | — | — | US | disclosed |
| US-10251872-B2 | Multisubstituted aromatic compounds as serine protease inhibitors | VERSEON CORPORATION (US) | 2019-04-09 | — | — | US | disclosed |
| US-10058541-B2 | Multisubstituted aromatic compounds as serine protease inhibitors | VERSEON CORPORATION (US) | 2018-08-28 | — | — | US | disclosed |
| US-20180064698-A1 | MULTISUBSTITUTED AROMATIC COMPOUNDS AS SERINE PROTEASE INHIBITORS | VERSEON INTERNATIONAL CORPORATION | 2018-03-08 | — | — | US | disclosed |
| US-20170258775-A1 | MULTISUBSTITUTED AROMATIC COMPOUNDS AS SERINE PROTEASE INHIBITORS | VERSEON INTERNATIONAL CORPORATION | 2017-09-14 | — | — | US | disclosed |
| US-9687479-B2 | Multisubstituted aromatic compounds as serine protease inhibitors | VERSEON CORPORATION (US) | 2017-06-27 | — | — | US | disclosed |
| US-20170065570-A1 | MULTISUBSTITUTED AROMATIC COMPOUNDS AS SERINE PROTEASE INHIBITORS | VERSEON INTERNATIONAL CORPORATION | 2017-03-09 | — | — | US | disclosed |
| US-9533970-B2 | Multisubstituted aromatic compounds as serine protease inhibitors | VERSEON CORPORATION (US) | 2017-01-03 | — | — | US | disclosed |
| US-20160024047-A1 | MULTISUBSTITUTED AROMATIC COMPOUNDS AS SERINE PROTEASE INHIBITORS | VERSEON INTERNATIONAL CORPORATION | 2016-01-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190142813-A1 | MULTISUBSTITUTED AROMATIC COMPOUNDS AS SERINE PROTEASE INHIBITORS | SPINT2, PRSS1, SERPINB1 | HSD17B10 1964/4885HTT 1541/4885HDAC3 1195/4885 |
| US-20180064698-A1 | MULTISUBSTITUTED AROMATIC COMPOUNDS AS SERINE PROTEASE INHIBITORS | SPINT2, PRSS1, SERPINB1 | HSD17B10 1964/4885HTT 1541/4885HDAC3 1195/4885 |
| US-10251872-B2 | Multisubstituted aromatic compounds as serine protease inhibitors | SPINT2, PRSS1, SERPINB1 | HSD17B10 1964/4885HTT 1541/4885HDAC3 1195/4885 |
| US-10058541-B2 | Multisubstituted aromatic compounds as serine protease inhibitors | SPINT2, PRSS1, SERPINB1 | HSD17B10 1964/4885HTT 1541/4885HDAC3 1195/4885 |
| US-20160024047-A1 | MULTISUBSTITUTED AROMATIC COMPOUNDS AS SERINE PROTEASE INHIBITORS | SPINT2, PRSS1, SERPINB1 | HSD17B10 1964/4885HTT 1541/4885HDAC3 1195/4885 |
| US-20170065570-A1 | MULTISUBSTITUTED AROMATIC COMPOUNDS AS SERINE PROTEASE INHIBITORS | SPINT2, PRSS1, SERPINB1 | HSD17B10 1964/4885HTT 1541/4885HDAC3 1195/4885 |
| US-20170258775-A1 | MULTISUBSTITUTED AROMATIC COMPOUNDS AS SERINE PROTEASE INHIBITORS | SPINT2, PRSS1, SERPINB1 | HSD17B10 1964/4885HTT 1541/4885HDAC3 1195/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.