Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.39 |
| ▸ | TDO2 | P48775 | 2/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CDC7 | O00311 | 1/20 | 0.35 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17461544 | 0.75 | MAPK10 (0.38) | MAPTPTGS1PTGS2MAPK10RAB9A | |
| SCHEMBL13393495 | 0.70 | SMN1; SMN2 (0.42) | MAPTTDO2MEN1KMT2AALDH1A1 | |
| SCHEMBL17461539 | 0.66 | RAB9A (0.52) | MAPTIDO1PTGS1PTGS2TDO2 | |
| SCHEMBL28255593 | 0.65 | DHODH (0.51) | MAPTRAB9ANPC1DHODHCDC7 | |
| SCHEMBL16481316 | 0.64 | LMNA (0.62) | MAPTRAB9ANPC1MEN1LMNA | |
| SCHEMBL15673390 | 0.64 | ERBB2 (0.66) | MAPTHTT | |
| SCHEMBL17461534 | 0.64 | PTGS1 (0.46) | MAPTIDO1PTGS1PTGS2TDO2 | |
| SCHEMBL4715551 | 0.63 | NPC1 (0.39) | MAPTMAPK10RAB9ANPC1MEN1 | |
| SCHEMBL3715325 | 0.61 | LRRK2 (0.53) | MAPTRAB9ANPC1MEN1LMNA | |
| SCHEMBL24283166 | 0.61 | MAPK10 (0.37) | MAPTPTGS1PTGS2MAPK10RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346868-B1 | AZAINDAZOLE COMPOUNDS AS CCR1 RECEPTOR ANTAGONISTS | BOEHRINGER INGELHEIM INT (DE) | 2016-01-27 | — | — | EP | disclosed |