SCHEMBL1746557

SCHEMBL1746557

O=C(O)CCc1ccc(OCc2cc(Br)ccc2Cl)cc1

nearest known ligand 0.67

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 20/20 0.67
FFAR4 Q5NUL3 12/20 0.67
AKR1B1 P15121 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1744973 0.86 FFAR1 (0.49) FFAR1FFAR4
SCHEMBL1745284 0.82 FFAR1 (0.70) FFAR1FFAR4AKR1B1
SCHEMBL1747411 0.82 FFAR1 (0.66) FFAR1FFAR4AKR1B1
SCHEMBL28927524 0.81 FFAR1 (0.67) FFAR1FFAR4AKR1B1
SCHEMBL30172568 0.81 FFAR1 (0.67) FFAR1FFAR4AKR1B1
SCHEMBL15211124 0.79 FFAR1 (0.72) FFAR1FFAR4AKR1B1
SCHEMBL31690287 0.79 NPSR1 (0.44) FFAR1FFAR4
SCHEMBL1998296 0.77 FFAR1 (1.00) FFAR1FFAR4AKR1B1
SCHEMBL1767679 0.77 MAOB (0.49)
SCHEMBL12577954 0.74 ALDH1A1 (0.45)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1559422-B1 RECEPTOR FUNCTION CONTROLLING AGENT TAKEDA PHARMACEUTICAL (JP) 2014-04-30 EP disclosed
EP-2385032-A1 GPR40 Receptor function regulator Takeda Pharmaceutical Company Limited (JP) 2011-11-09 EP disclosed
US-7960369-B2 Receptor function regulator TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2011-06-14 US disclosed
US-20090012093-A1 Receptor Function Regulator TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2009-01-08 US disclosed
EP-1559422-A1 RECEPTOR FUNCTION CONTROLLING AGENT Takeda Pharmaceutical Company Limited (JP) 2005-08-03 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090012093-A1 Receptor Function Regulator GPR119, GIPR, INSR FFAR1 33/4885FFAR4 44/4885AKR1B1 1186/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.