Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAX8 | Q06710 | 1/20 | 0.37 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.32 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | TTK | P33981 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17467122 | 0.87 | BACE1 (0.37) | PAX8AAK1MTNR1AMTNR1BKDM4E | |
| SCHEMBL8234275 | 0.84 | PAX8 (0.38) | PAX8MTNR1AMTNR1BKDM4EALDH1A1 | |
| SCHEMBL15587576 | 0.83 | PAX8 (0.37) | PAX8AAK1MTNR1AMTNR1BKDM4E | |
| SCHEMBL15545096 | 0.81 | KDM4E (0.39) | KDM4EALDH1A1POLBL3MBTL1MEN1 | |
| SCHEMBL4070313 | 0.79 | ALDH1A1 (0.40) | PAX8MTNR1AMTNR1BKDM4EALDH1A1 | |
| SCHEMBL8226698 | 0.79 | MTNR1A (0.35) | PAX8AAK1MTNR1AMTNR1BKDM4E | |
| SCHEMBL17467163 | 0.79 | PAX8 (0.38) | PAX8AAK1BACE1POLBTTK | |
| SCHEMBL8236816 | 0.75 | KMT2A (0.40) | MTNR1AMTNR1BKDM4EALDH1A1POLB | |
| SCHEMBL4064565 | 0.75 | PAX8 (0.34) | PAX8MTNR1AMTNR1BKDM4EITGA4 | |
| SCHEMBL17467171 | 0.74 | L3MBTL1 (0.36) | KDM4EALDH1A1L3MBTL1MEN1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9249160-B2 | Orexin receptor antagonists | HEPTARES THERAPEUTICS LIMITED (GB) | 2016-02-02 | — | — | US | disclosed |