Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 1/20 | 0.37 |
| ▸ | LTA4H | P09960 | 2/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.32 |
| ▸ | CHRNA10 | Q9GZZ6 | 1/20 | 0.32 |
| ▸ | CHRNA9 | Q9UGM1 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL100765 | 0.76 | HPGDS (0.46) | HPGDSLTA4HADRA1DADRA1AADRA1B | |
| SCHEMBL1920363 | 0.70 | LTA4H (0.36) | HPGDSLTA4HADRA1DADRA1AADRA1B | |
| SCHEMBL7229227 | 0.70 | HPGDS (0.33) | HPGDSLTA4HADRA1DADRA1AADRA1B | |
| SCHEMBL6440986 | 0.67 | HPGDS (0.32) | HPGDSLTA4H | |
| SCHEMBL722557 | 0.67 | LTA4H (0.64) | HPGDSLTA4HCHRNA7CHRNA10CHRNA9 | |
| SCHEMBL23629116 | 0.67 | — | — | |
| SCHEMBL28723235 | 0.66 | HPGDS (0.33) | HPGDSLTA4H | |
| SCHEMBL66901 | 0.65 | HPGDS (0.48) | HPGDSLTA4HADRA1DADRA1AADRA1B | |
| SCHEMBL28320605 | 0.65 | LTA4H (0.62) | HPGDSLTA4HCHRNA7CHRNA10CHRNA9 | |
| SCHEMBL28362996 | 0.65 | LTA4H (0.62) | HPGDSLTA4HADRA1DADRA1ACHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE47009-E1 | HDAC inhibitors and therapeutic methods using the same | THE CHILDREN'S HOSPITAL OF PHILADELPHIA (US) | 2018-08-28 | — | — | US | claimed |
| US-9249087-B2 | HDAC inhibitors and therapeutic methods using the same | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2016-02-02 | — | — | US | claimed |