SCHEMBL17469397

SCHEMBL17469397

CC(=O)c1c(C)cc(-c2cccc(Br)c2)cc1/C=C/c1ccccc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.42
MAPT P10636 3/20 0.40
KMT2A Q03164 3/20 0.40
CCR6 P51684 1/20 0.40
MAOB P27338 4/20 0.40
MAOA P21397 3/20 0.40
BCL2L1 Q07817 1/20 0.39
BAD Q92934 1/20 0.39
HSD17B3 P37058 1/20 0.38
SENP1 Q9P0U3 1/20 0.37
GAA P10253 1/20 0.37
RELA Q04206 1/20 0.36
TTR P02766 1/20 0.36
ALOX5 P09917 1/20 0.36
PTGS1 P23219 1/20 0.36
PTGS2 P35354 1/20 0.36
PRNP P04156 1/20 0.35
PPARG P37231 1/20 0.35
RXFP1 Q9HBX9 1/20 0.35
NR2E3 Q9Y5X4 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17469313 0.88 TTR (0.42) ALDH1A1MAPTKMT2ABCL2L1BAD
SCHEMBL17469394 0.83 BCHE (0.46) ALDH1A1MAPTKMT2AMAOBRELA
SCHEMBL17469392 0.82 CYP1B1 (0.42) ALDH1A1MAPTBCL2L1BADGAA
SCHEMBL17469314 0.81 RELA (0.42) BCL2L1BADRELATTRALOX5
SCHEMBL17469356 0.80 BCL2L1 (0.38) MAPTBCL2L1BADGAATTR
SCHEMBL17459521 0.79 BCL2L1 (0.46) ALDH1A1MAPTKMT2ABCL2L1BAD
SCHEMBL17459520 0.79 BCL2L1 (0.46) ALDH1A1MAPTKMT2ABCL2L1BAD
SCHEMBL17469335 0.78 TRPA1 (0.48) ALDH1A1MAPTKMT2AMAOBMAOA
SCHEMBL17469357 0.76 ERN1 (0.40) ALDH1A1MAPTKMT2AMAOBMAOA
SCHEMBL17469358 0.76 TNFRSF1A (0.42) ALDH1A1MAPTKMT2ALMNARAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2016013976-A1 METHOD OF FORMING A MULTI-SUBSTITUTED BENZENE COMPOUND NANYANG TECHNOLOGICAL UNIVERSITY (SG) 2016-01-28 WO disclosed