SCHEMBL17469356

SCHEMBL17469356

CC(=O)c1c(C)cc(-c2ccc(I)cc2)cc1/C=C/c1ccccc1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BCL2L1 Q07817 1/20 0.38
BAD Q92934 1/20 0.38
TTR P02766 1/20 0.38
ALOX5 P09917 1/20 0.38
PTGS1 P23219 1/20 0.38
PTGS2 P35354 1/20 0.38
GLA P06280 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
GAA P10253 1/20 0.36
MAPT P10636 2/20 0.35
LMNA P02545 1/20 0.35
HTT P42858 1/20 0.35
NFE2L2 Q16236 1/20 0.35
SMN1; SMN2 Q16637 2/20 0.34
CHAT P28329 1/20 0.34
TUBB4A P04350 1/20 0.34
TUBB P07437 1/20 0.34
TUBA3C P0DPH7 1/20 0.34
TUBA1B P68363 1/20 0.34
TUBA4A P68366 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17469313 0.91 TTR (0.42) BCL2L1BADTTRALOX5PTGS1
SCHEMBL17469392 0.90 CYP1B1 (0.42) BCL2L1BADTTRALOX5PTGS1
SCHEMBL17469335 0.85 TRPA1 (0.48) MAPTLMNASMN1; SMN2TUBB4ATUBB
SCHEMBL17469314 0.84 RELA (0.42) BCL2L1BADTTRALOX5PTGS1
SCHEMBL17459521 0.81 BCL2L1 (0.46) BCL2L1BADTTRALOX5PTGS1
SCHEMBL17459520 0.81 BCL2L1 (0.46) BCL2L1BADTTRALOX5PTGS1
SCHEMBL17469397 0.80 ALDH1A1 (0.42) BCL2L1BADTTRALOX5PTGS1
SCHEMBL17469394 0.78 BCHE (0.46) MAPTNFE2L2SMN1; SMN2KDM4E
SCHEMBL17469357 0.78 ERN1 (0.40) TTRALOX5PTGS1PTGS2GLA
SCHEMBL17469358 0.78 TNFRSF1A (0.42) MAPTLMNASMN1; SMN2KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2016013976-A1 METHOD OF FORMING A MULTI-SUBSTITUTED BENZENE COMPOUND NANYANG TECHNOLOGICAL UNIVERSITY (SG) 2016-01-28 WO disclosed