SCHEMBL17469394

SCHEMBL17469394

COc1cccc(-c2cc(C)c(C(C)=O)c(/C=C/c3ccccc3)c2)c1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BCHE P06276 1/20 0.46
MAOB P27338 1/20 0.46
NFE2L2 Q16236 3/20 0.46
RELA Q04206 1/20 0.45
ERN1 O75460 1/20 0.44
CYP1A1 P04798 2/20 0.44
CYP1A2 P05177 2/20 0.44
CYP1B1 Q16678 2/20 0.44
CASP3 P42574 1/20 0.44
SENP8 Q96LD8 1/20 0.44
SENP7 Q9BQF6 1/20 0.44
SENP6 Q9GZR1 1/20 0.44
MMP1 P03956 1/20 0.44
MMP2 P08253 1/20 0.44
MMP9 P14780 1/20 0.44
MEN1 O00255 2/20 0.43
ALDH1A1 P00352 2/20 0.43
KMT2A Q03164 2/20 0.43
FOS P01100 1/20 0.43
JUN P05412 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17469335 0.88 TRPA1 (0.48) BCHEMAOBRELACYP1A1CYP1A2
SCHEMBL17469313 0.86 TTR (0.42) NFE2L2ALDH1A1KMT2AMAPTSMN1; SMN2
SCHEMBL17469397 0.83 ALDH1A1 (0.42) MAOBRELAALDH1A1KMT2AMAPT
SCHEMBL17469314 0.82 RELA (0.42) NFE2L2RELAERN1CYP1B1
SCHEMBL17469392 0.80 CYP1B1 (0.42) NFE2L2CYP1A2CYP1B1MMP1MMP2
SCHEMBL17459513 0.80 TRPA1 (0.49) BCHEMAOBRELACYP1A1CYP1A2
SCHEMBL17459512 0.80 TRPA1 (0.49) BCHEMAOBRELACYP1A1CYP1A2
SCHEMBL17469356 0.78 BCL2L1 (0.38) NFE2L2KDM4EMAPTSMN1; SMN2
SCHEMBL17469387 0.78 RAB9A (0.45) NFE2L2CYP1A2MEN1ALDH1A1KMT2A
SCHEMBL17459521 0.77 BCL2L1 (0.46) NFE2L2ALDH1A1KMT2AMAPTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2016013976-A1 METHOD OF FORMING A MULTI-SUBSTITUTED BENZENE COMPOUND NANYANG TECHNOLOGICAL UNIVERSITY (SG) 2016-01-28 WO disclosed