Sugi Predict

Sugi Predict / Compounds / SCHEMBL174735

SCHEMBL174735

SCHEMBL174735

O=c1ccnc2ccccn12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ADORA3 P0DMS8 2/20 1.00
▸ GRM5 P41594 2/20 0.54
▸ KDM4E B2RXH2 4/20 0.43
▸ ALDH1A1 P00352 2/20 0.43
▸ GLA P06280 2/20 0.43
▸ GAA P10253 2/20 0.43
▸ HPGD P15428 2/20 0.43
▸ HSD17B10 Q99714 2/20 0.43
▸ NPC1 O15118 1/20 0.43
▸ CASP1 P29466 1/20 0.43
▸ CASP7 P55210 1/20 0.43
▸ DYRK1A Q13627 2/20 0.43
▸ CHEK1 O14757 1/20 0.43
▸ MAP4K4 O95819 1/20 0.43
▸ CSF1R P07333 1/20 0.43
▸ PRKACA P17612 1/20 0.43
▸ KDR P35968 1/20 0.43
▸ CDK8 P49336 1/20 0.43
▸ MAP2K1 Q02750 1/20 0.43
▸ ACVR1 Q04771 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL5127992 0.98 ADORA3 (0.96) ADORA3GRM5KDM4EALDH1A1GLA
Hydrochloric Acid SCHEMBL5129999 0.98 ADORA3 (0.96) ADORA3GRM5KDM4EALDH1A1GLA
Hydrochloric Acid SCHEMBL10598992 0.98 ADORA3 (0.96) ADORA3GRM5KDM4EALDH1A1GLA
Trifluoroacetic Acid SCHEMBL5132448 0.85 ADORA3 (0.73) ADORA3GRM5KDM4EALDH1A1GLA
SCHEMBL3326263 0.83 ADORA3 (0.71) ADORA3GRM5KDM4EALDH1A1GLA
SCHEMBL20602860 0.78 ADORA3 (0.61) ADORA3GRM5KDM4EHPGDHSD17B10
Purine SCHEMBL6010896 0.77 ADORA3 (0.58) ADORA3GRM5KDM4EALDH1A1GLA
SCHEMBL29536061 0.75 ADORA3 (0.60) ADORA3KDM4EALDH1A1GLAGAA
SCHEMBL15174581 0.75 ADORA3 (0.60) ADORA3GRM5KDM4EALDH1A1GAA
SCHEMBL3928007 0.75 ADORA3 (0.56) ADORA3GRM5KDM4EALDH1A1GLA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 975 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3645121-B1 METHODS FOR TREATING HUNTINGTON'S DISEASE PTC THERAPEUTICS INC (US) 2025-05-14 — — EP claimed
CN-119528903-A Compounds for the treatment of spinal muscular atrophy PTC医疗公司 2025-02-28 — — CN claimed
CN-119504744-A C3 arylformyloxy 4H-pyrido [1,2-a ] pyrimidine-4-ketone derivative and synthetic method thereof 山西医科大学 2025-02-25 — — CN claimed
EP-4490162-A1 PYRIDO[1,2-A]PYRIMIDIN-4-ONE DERIVATIVES F. Hoffmann-La Roche AG (CH) 2025-01-15 — — EP claimed
US-20250002475-A1 PIPERIDINE DERIVATIVES AS METTL3 INHIBITORS EPICS THERAPEUTICS (BE) 2025-01-02 — — US claimed
CN-118994154-A C3 fluoroalkylation 4H-pyrido [1,2-a ] pyrimidine-4-ketone derivative and synthesis method thereof 山西医科大学 2024-11-22 — — CN claimed
US-12091400-B2 Piperidine derivatives as METTL3 inhibitors EPICS THERAPEUTICS (BE) 2024-09-17 — — US claimed
US-20240270716-A1 PIPERIDINE DERIVATIVES AS METTL3 INHIBITORS EPICS THERAPEUTICS (BE) 2024-08-15 — — US claimed
WO-2024112763-A9 SELECTION OF PATIENTS FOR THE TREATMENT OF FADS1-MEDIATED DISEASES OR DISORDERS USING FADS-1 INHIBITORS AMGEN INC. (US) 2024-07-11 — — WO claimed
CN-111182898-B Methods for treating huntington's disease PTC医疗公司 2024-04-16 — — CN claimed
US-6479484-B1 SUBSTITUTED 2-AMINOACETAMIDES AND THE DISCOVERY THAT THESE COMPOUNDS ACT AS BLOCKERS OF SODIUM CHANNELS; PAIN RELIEVERS, TREATMENT OF ARRYTHMIA, LOCAL ANESTHETICS EURO-CELTIQUE S.A. (LU) 2002-11-12 — — US claimed
WO-2002047690-A1 SUBSTITUTED 2-ARYL-4-ARYLAMINOPYRIMIDINES AND ANALOGS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF CYTOVIA, INC. (US) 2002-06-20 — — WO claimed
EP-0808313-A1 ANTIPSYCHOTIC 4-(1H-INDOLYL-1-YL)-1-SUBSTITUTED PIPERIDINE DERIVATIVES JANSSEN PHARMACEUTICA N.V. (BE) 1997-11-26 — — EP claimed
EP-0733633-A1 Heterocyclic compounds, their production and use TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1996-09-25 — — EP claimed
WO-1996023784-A1 ANTIPSYCHOTIC 4-(1H-INDOLYL-1-YL)-1-SUBSTITUTED PIPERIDINE DERIVATIVES JANSSEN PHARMACEUTICA N.V. (BE) 1996-08-08 — — WO claimed
WO-1993004065-A1 NEW 3-(SUBSTITUTED TETRAZOLYL)-4-OXO-4H-PYRIDO-[1,2-a]PYRIMIDINES, SALTS THEREOF, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR PREPARING SAME CHINOIN GYÓGYSZER- ÉS VEGYÉSZETI TERMÉKEK GYÁRA RT. (HU) 1993-03-04 — — WO claimed
EP-0217673-B1 Pyrido [1,2-a]pyrimidine derivatives TOKYO TANABE COMPANY LIMITED (JP) 1989-12-27 — — EP claimed
EP-0037265-B1 3-(1-PIPERIDINYLALKYL)-4H-PYRIDO(1,2-A)PYRIMIDIN-4-ONE DERIVATIVES JANSSEN PHARMACEUTICA N.V. (BE) 1985-01-23 — — EP claimed
US-4342870-A SEROTONIN ANTAGONISTS JANSSEN PHARMACEUTICA N.V. (BE) 1982-08-03 — — US claimed
EP-0037265-A1 3-(1-piperidinylalkyl)-4H-pyrido(1,2-a)pyrimidin-4-one derivatives JANSSEN PHARMACEUTICA N.V. (BE) 1981-10-07 — — EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240270716-A1 PIPERIDINE DERIVATIVES AS METTL3 INHIBITORS METTL3, METTL16, DIMT1 ADORA3 50/4885GRM5 2318/4885KDM4E 872/4885
US-20250002475-A1 PIPERIDINE DERIVATIVES AS METTL3 INHIBITORS METTL3, METTL16, DIMT1 ADORA3 50/4885GRM5 2318/4885KDM4E 872/4885
US-12091400-B2 Piperidine derivatives as METTL3 inhibitors METTL3, METTL16, DIMT1 ADORA3 50/4885GRM5 2318/4885KDM4E 872/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.