Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.71 |
| ▸ | CDK8 | P49336 | 2/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
| ▸ | PRKACA | P17612 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.43 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.43 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.43 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.43 |
| ▸ | GRM5 | P41594 | 3/20 | 0.42 |
| ▸ | FLT1 | P17948 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 1/20 | 0.39 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL174735 | 0.83 | ADORA3 (1.00) | ADORA3CDK8ROCK1CHEK1MAP4K4 | |
| Hydrochloric Acid SCHEMBL5127992 | 0.82 | ADORA3 (0.96) | ADORA3CDK8ROCK1CHEK1MAP4K4 | |
| Hydrochloric Acid SCHEMBL5129999 | 0.82 | ADORA3 (0.96) | ADORA3CDK8ROCK1CHEK1MAP4K4 | |
| Hydrochloric Acid SCHEMBL10598992 | 0.82 | ADORA3 (0.96) | ADORA3CDK8ROCK1CHEK1MAP4K4 | |
| SCHEMBL30724570 | 0.75 | ADORA3 (0.55) | ADORA3CDK8ROCK1CHEK1MAP4K4 | |
| SCHEMBL6469168 | 0.72 | ADORA3 (0.57) | ADORA3DYRK1AGRM5KDM4EALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL5132448 | 0.71 | ADORA3 (0.73) | ADORA3CDK8ROCK1CHEK1MAP4K4 | |
| Hydrochloric Acid SCHEMBL6445246 | 0.71 | ADORA3 (0.55) | ADORA3DYRK1AGRM5KDM4EALDH1A1 | |
| SCHEMBL20223111 | 0.69 | ADORA3 (0.44) | ADORA3CDK8ROCK1CHEK1MAP4K4 | |
| SCHEMBL19153793 | 0.68 | ADORA3 (0.42) | ADORA3CDK8ROCK1CHEK1MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240067646-A1 | COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY | HOFFMANN-LA ROCHE INC. | 2024-02-29 | — | — | US | disclosed |
| US-20230310651-A1 | METHODS FOR MODULATING RNA SPLICING | PTC THERAPEUTICS, INC. (US) | 2023-10-05 | — | — | US | disclosed |
| US-11753407-B2 | Compounds for treating spinal muscular atrophy | PTC THERAPEUTICS, INC. (US) | 2023-09-12 | — | — | US | disclosed |
| US-20230272367-A1 | METHODS FOR MODULATING RNA SPLICING | PTC THERAPEUTICS, INC. (US) | 2023-08-31 | — | — | US | disclosed |
| US-11702646-B2 | Methods for modulating RNA splicing | PTC THERAPEUTICS, INC. (US) | 2023-07-18 | — | — | US | disclosed |
| US-20180161456-A1 | METHODS FOR MODULATING RNA SPLICING | PTC THERAPEUTICS, INC. (US) | 2018-06-14 | — | — | US | disclosed |
| US-20180105526-A1 | COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY | PTC THERAPEUTICS INC (US) | 2018-04-19 | — | — | US | disclosed |
| US-9879007-B2 | Compounds for treating spinal muscular atrophy | PTC THERAPEUTICS, INC. (US) | 2018-01-30 | — | — | US | disclosed |
| US-20170129885-A1 | COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY | HOFFMANN-LA ROCHE INC. | 2017-05-11 | — | — | US | disclosed |
| US-9586955-B2 | Compounds for treating spinal muscular atrophy | PTC THERAPEUTICS, INC. (US) | 2017-03-07 | — | — | US | disclosed |
| US-20170000794-A1 | METHODS FOR MODULATING THE AMOUNT OF RNA TRANSCRIPTS | PTC THERAPEUTICS, INC. | 2017-01-05 | — | — | US | disclosed |
| US-20150005289-A1 | COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY | HOFFMANN-LA ROCHE INC. | 2015-01-01 | — | — | US | disclosed |
| US-20100137230-A1 | NEW PYRIDIN-2-ONE COMPOUNDS | WEBER LUTZ | 2010-06-03 | — | — | US | disclosed |
| US-20080176860-A1 | PYRIDIN-2-ONE COMPOUNDS | WEBER LUTZ | 2008-07-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240067646-A1 | COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY | SMN1; SMN2, CPT1B, GYS1 | ADORA3 2909/4885CDK8 3266/4885ROCK1 3127/4885 |
| US-20080176860-A1 | PYRIDIN-2-ONE COMPOUNDS | SLC11A2, ABCC1, DHFR | ADORA3 3047/4885CDK8 1392/4885ROCK1 3303/4885 |
| US-20150005289-A1 | COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY | SMN1; SMN2, CPT1B, GYS1 | ADORA3 3003/4885CDK8 2697/4885ROCK1 3287/4885 |
| US-20230272367-A1 | METHODS FOR MODULATING RNA SPLICING | RBM17, SNRPE, HNRNPM | ADORA3 4274/4885CDK8 3303/4885ROCK1 3572/4885 |
| US-20180105526-A1 | COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY | SMN1; SMN2, CPT1B, GYS1 | ADORA3 3003/4885CDK8 2697/4885ROCK1 3287/4885 |
| US-11702646-B2 | Methods for modulating RNA splicing | RBM17, SNRPE, HNRNPM | ADORA3 4274/4885CDK8 3303/4885ROCK1 3572/4885 |
| US-20100137230-A1 | NEW PYRIDIN-2-ONE COMPOUNDS | ABCC1, BLVRB, NDUFS5 | ADORA3 2311/4885CDK8 1079/4885ROCK1 3540/4885 |
| US-20180161456-A1 | METHODS FOR MODULATING RNA SPLICING | RBM17, SNRPE, RBM3 | ADORA3 3782/4885CDK8 3335/4885ROCK1 3299/4885 |
| US-20170000794-A1 | METHODS FOR MODULATING THE AMOUNT OF RNA TRANSCRIPTS | RNMT, NSUN2, RNGTT | ADORA3 4221/4885CDK8 2619/4885ROCK1 3138/4885 |
| US-20170129885-A1 | COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY | SMN1; SMN2, CPT1B, GYS1 | ADORA3 3003/4885CDK8 2697/4885ROCK1 3287/4885 |
| US-20230310651-A1 | METHODS FOR MODULATING RNA SPLICING | RBM17, SNRPE, RBM3 | ADORA3 3782/4885CDK8 3335/4885ROCK1 3299/4885 |
| US-11753407-B2 | Compounds for treating spinal muscular atrophy | SMN1; SMN2, CPT1B, GYS1 | ADORA3 1293/4885CDK8 1821/4885ROCK1 3428/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.