Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.54 |
| ▸ | PLA2G4B | P0C869 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 4/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.46 |
| ▸ | TSHR | P16473 | 4/20 | 0.46 |
| ▸ | GAA | P10253 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | RGS12 | O14924 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | APEX1 | P27695 | 1/20 | 0.46 |
| ▸ | THPO | P40225 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12164760 | 0.86 | BCL2 (0.46) | CYP1A2CYP2C19HPGDTSHRGAA | |
| SCHEMBL70565 | 0.85 | AKR1B1 (0.71) | CYP1A2CYP2C19AKR1B1HPGDHSD17B10 | |
| SCHEMBL1515871 | 0.84 | AKR1B1 (0.58) | CYP1A2CYP2C19AKR1B1HPGDHSD17B10 | |
| SCHEMBL17481548 | 0.84 | ALDH1A1 (0.59) | AKR1B1PLA2G4BHPGDHSD17B10TSHR | |
| Hydrochloric Acid SCHEMBL8922940 | 0.83 | AKR1B1 (0.68) | CYP1A2CYP2C19AKR1B1HPGDHSD17B10 | |
| SCHEMBL14704483 | 0.82 | AKR1B1 (0.56) | CYP1A2CYP2C19AKR1B1HPGDHSD17B10 | |
| SCHEMBL43241 | 0.81 | CES1 (0.58) | AKR1B1TSHRTDP1POLBALDH1A1 | |
| Benzene SCHEMBL27614820 | 0.81 | CES1 (0.58) | AKR1B1TSHRTDP1POLBALDH1A1 | |
| SCHEMBL15042342 | 0.81 | AKR1B1 (0.54) | CYP1A2CYP2C19AKR1B1PLA2G4BHPGD | |
| SCHEMBL2436067 | 0.81 | CTBP2 (0.56) | HPGDTDP1POLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170015707-A1 | COVALENT GRANZYME B INHIBITORS | VIDA THERAPEUTICS INC. (CA) | 2017-01-19 | — | — | US | disclosed |
| US-20170015705-A1 | PYRROLE COMPOUNDS AS GRANZYME B INHIBITORS | VIDA THERAPEUTICS INC. (CA) | 2017-01-19 | — | — | US | disclosed |
| WO-2016015160-A1 | CYCLIC UREA COMPOUNDS AS GRANZYME B INHIBITORS | VIDA THERAPEUTICS, INC. (CA) | 2016-02-04 | — | — | WO | disclosed |
| WO-2016015159-A1 | AZAINDOLINE COMPOUNDS AS GRANZYME B INHIBITORS | VIDA THERAPEUTICS, INC. (CA) | 2016-02-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170015705-A1 | PYRROLE COMPOUNDS AS GRANZYME B INHIBITORS | GZMB, CTSB, DNASE1L3 | CYP1A2 4345/4885CYP2C19 3404/4885AKR1B1 2476/4885 |
| US-20170015707-A1 | COVALENT GRANZYME B INHIBITORS | GZMB, CTSB, DNASE1L3 | CYP1A2 4154/4885CYP2C19 2974/4885AKR1B1 2812/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.