Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | BCL2 | P10415 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 5/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | RGS12 | O14924 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | APEX1 | P27695 | 1/20 | 0.48 |
| ▸ | THPO | P40225 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.48 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL70565 | 0.89 | AKR1B1 (0.71) | AKR1B1CYP1A2CYP2C19HPGDHSD17B10 | |
| Hydrochloric Acid SCHEMBL8922940 | 0.87 | AKR1B1 (0.68) | AKR1B1CYP1A2CYP2C19HPGDHSD17B10 | |
| Acetic Acid SCHEMBL27734248 | 0.85 | BCL2 (0.56) | BCL2HPGDTSHRMAPTTDP1 | |
| Hydrogen Peroxide SCHEMBL11520377 | 0.84 | TP53 (0.63) | CYP1A2BCL2MAPTPTGS2TP53 | |
| SCHEMBL17481539 | 0.84 | CYP1A2 (0.54) | AKR1B1CYP1A2CYP2C19HPGDHSD17B10 | |
| SCHEMBL15042342 | 0.84 | AKR1B1 (0.54) | AKR1B1CYP1A2CYP2C19HPGDHSD17B10 | |
| SCHEMBL729924 | 0.83 | AKR1B1 (0.58) | AKR1B1CYP1A2CYP2C19HPGDHSD17B10 | |
| SCHEMBL13905068 | 0.83 | BCL2 (0.47) | CYP1A2CYP2C19BCL2HPGDTSHR | |
| SCHEMBL4402323 | 0.83 | AKR1B1 (0.62) | AKR1B1CYP1A2CYP2C19HPGDHSD17B10 | |
| SCHEMBL6491963 | 0.82 | THRB (0.50) | AKR1B1HPGDHSD17B10KDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022218379-A1 | SMALL-MOLECULE COMPOUND HAVING SUBSTITUTED PHENYL SPIRO[INDOLINE-3,3'-PYRROLIDINE] STRUCTURE | 中国科学院上海药物研究所 | 2022-10-20 | — | — | WO | disclosed |
| US-9714240-B2 | Vinyl autotaxin inhibitor compounds | PHARMAKEA, INC. (US) | 2017-07-25 | — | — | US | disclosed |
| US-9283229-B2 | Dihydropyrimidin-2(1H)-one compounds as S-nitrosoglutathione reductase inhibitors | NIVALIS THERAPEUTICS, INC. (US) | 2016-03-15 | — | — | US | disclosed |
| US-20150361126-A1 | ANDROGEN RECEPTOR DOWN-REGULATING AGENTS AND USES THEREOF | UNIVERSITY OF MARYLAND, BALTIMORE | 2015-12-17 | — | — | US | disclosed |
| EP-2373634-B1 | MORPHOLINONE COMPOUNDS AS FACTOR IXA INHIBITORS | MOCHIDA PHARM CO LTD (JP) | 2015-11-11 | — | — | EP | disclosed |
| US-20150224107-A1 | Novel Dihydropyrimidin-2(1H)-one Compounds as S-Nitrosoglutathione Reductase Inhibitors | N30 PHARMACEUTICALS, LLC | 2015-08-13 | — | — | US | disclosed |
| US-9067893-B2 | Dihydropyrimidin-2(1H)-one compounds as S-nitrosoglutathione reductase inhibitors | NIVALIS THERAPEUTICS, INC. (US) | 2015-06-30 | — | — | US | disclosed |
| US-9062028-B2 | Bicyclic nitrogen containing heteroaryl TGR5 receptor modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2015-06-23 | — | — | US | disclosed |
| US-20140235640-A1 | Novel Dihydropyrimidin-2(1H)-one Compounds as S-Nitrosoglutathione Reductase Inhibitors | N30 PHARMACEUTICALS, INC. (US) | 2014-08-21 | — | — | US | disclosed |
| US-8741915-B2 | Dihydropyrimidin-2(1H)-one compounds as S-nitrosoglutathione reductase inhibitors | N30 PHARMACEUTICALS, INC. (US) | 2014-06-03 | — | — | US | disclosed |
| US-20100137294-A1 | COMPOUNDS, COMPOSITIONS AND METHODS FOR CONTROLLING INVERTEBRATE PESTS | GENETIC TECHNOLOGIES LIMITED (AU) | 2010-06-03 | — | — | US | disclosed |
| US-20090298807-A1 | Compounds | ASTRAZENECA AB (SE) | 2009-12-03 | — | — | US | disclosed |
| US-7601754-B2 | Flavonoid compounds as therapeutic antioxidants | ANTOXIS LIMITED (GB) | 2009-10-13 | — | — | US | disclosed |
| US-7514468-B2 | Indolinone derivatives substituted in the 6 position, the preparation thereof and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2009-04-07 | — | — | US | disclosed |
| WO-2008063714-A1 | METABOLICALLY-STABILIZED INHIBITORS OF FATTY ACID AMIDE HYDROLASE | N.V. ORGANON (NL) | 2008-05-29 | — | — | WO | disclosed |
| EP-1534698-B1 | FLAVONOID COMPOUNDS AS THERAPEUTIC ANTIOXIDANTS | ROWETT RES INST (GB) | 2007-09-19 | — | — | EP | disclosed |
| US-20070066586-A1 | ANILINE DERIVATIVES | AJINOMOTO CO., INC. (JP) | 2007-03-22 | — | — | US | disclosed |
| US-20060137207-A1 | Flavonoid compounds as therapeutic antioxidants | ANTOXIS LIMITED (GB) | 2006-06-29 | — | — | US | disclosed |
| EP-1534698-A1 | FLAVONOID COMPOUNDS AS THERAPEUTIC ANTIOXIDANTS | The Rowett Research Institute (GB) | 2005-06-01 | — | — | EP | disclosed |
| WO-2004007475-A1 | FLAVONOID COMPOUNDS AS THERAPEUTIC ANTIOXIDANTS | ROWETT RESEARCH INSTITUTE (GB) | 2004-01-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140235640-A1 | Novel Dihydropyrimidin-2(1H)-one Compounds as S-Nitrosoglutathione Reductase Inhibitors | QDPR, GSR, CBR1 | AKR1B1 25/4885CYP1A2 169/4885CYP2C19 306/4885 |
| US-20150224107-A1 | Novel Dihydropyrimidin-2(1H)-one Compounds as S-Nitrosoglutathione Reductase Inhibitors | QDPR, GSR, CBR1 | AKR1B1 25/4885CYP1A2 169/4885CYP2C19 306/4885 |
| US-20100137294-A1 | COMPOUNDS, COMPOSITIONS AND METHODS FOR CONTROLLING INVERTEBRATE PESTS | PPP1R10, TASP1, PPP5C | AKR1B1 4380/4885CYP1A2 4492/4885CYP2C19 4747/4885 |
| US-20070066586-A1 | ANILINE DERIVATIVES | SERPINB1, ACE, REN | AKR1B1 86/4885CYP1A2 287/4885CYP2C19 172/4885 |
| US-20150361126-A1 | ANDROGEN RECEPTOR DOWN-REGULATING AGENTS AND USES THEREOF | AR, NR5A1, ESRRA | AKR1B1 86/4885CYP1A2 1994/4885CYP2C19 3671/4885 |
| US-20090298807-A1 | Compounds | PKD1, SLC10A1, ABCB11 | AKR1B1 75/4885CYP1A2 52/4885CYP2C19 15/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.