Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.80 |
| ▸ | LMNA | P02545 | 1/20 | 0.80 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.70 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.70 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.70 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.70 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.70 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.70 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.66 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | QPCT | Q16769 | 2/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | MAOB | P27338 | 1/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17482338 | 0.87 | KMT2A (0.80) | MAPTLMNAALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL10832667 | 0.83 | CYP1A2 (1.00) | MAPTLMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL10831942 | 0.82 | ALDH1A1 (1.00) | MAPTLMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL13197765 | 0.80 | MAPT (0.53) | MAPTLMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL10833053 | 0.80 | LMNA (0.76) | MAPTLMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL10832956 | 0.80 | ALOX15 (1.00) | MAPTLMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL10833298 | 0.79 | CYP1A2 (0.93) | MAPTLMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL10832177 | 0.78 | CYP1A2 (0.91) | MAPTLMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL10832419 | 0.78 | CYP1A2 (0.77) | MAPTLMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL10831908 | 0.76 | LMNA (0.71) | MAPTLMNACYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160031854-A1 | ACTIVATION OR REACTIVATION OF ACHE | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2016-02-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160031854-A1 | ACTIVATION OR REACTIVATION OF ACHE | ACHE, BCHE, CHAT | MAPT 2917/4885LMNA 2675/4885CYP1A2 1534/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.