Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 3/20 | 0.54 |
| ▸ | MAOB | P27338 | 3/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | TP53 | P04637 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | PRMT7 | Q9NVM4 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | HSF1 | Q00613 | 2/20 | 0.40 |
| ▸ | PIR | O00625 | 1/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | RHOA | P61586 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1747918 | 0.93 | MAOA (0.54) | MAOAMAOBCYP1A2CYP2C19MAPT | |
| SCHEMBL1748776 | 0.88 | MAOA (0.42) | MAOAMAOBMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL1747929 | 0.88 | MAOA (0.42) | MAOAMAOBMAPTRAB9ATP53 | |
| Hydrochloric Acid SCHEMBL1748935 | 0.87 | MAOA (0.42) | MAOAMAOBMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL1747910 | 0.86 | PIR (0.44) | MAOAMAOBMAPTRAB9ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL1747914 | 0.86 | MAOA (0.41) | MAOAMAOBMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL1747962 | 0.85 | MAOA (0.39) | MAOAMAOBCYP1A2RAB9ANPC1 | |
| SCHEMBL3196775 | 0.80 | MEN1 (0.40) | MAOAMAOBCYP1A2CYP2C19MAPT | |
| SCHEMBL3201640 | 0.80 | FGFR4 (0.41) | MAOAMAOBCYP1A2CYP2C19MAPT | |
| SCHEMBL3191800 | 0.80 | MAOA (0.50) | MAOAMAOBCYP1A2CYP2C19NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7968558-B2 | Amidine derivatives of 2-heteroaryl-quinazolines and quinolines; potent analgesics and anti-inflammatory agents | ROTTAPHARM S.P.A. (IT) | 2011-06-28 | — | — | US | disclosed |
| US-7968558-B2 | Amidine derivatives of 2-heteroaryl-quinazolines and quinolines; potent analgesics and anti-inflammatory agents | ROTTAPHARM S.P.A. (IT) | 2011-06-28 | — | — | US | disclosed |
| US-7968558-B2 | Amidine derivatives of 2-heteroaryl-quinazolines and quinolines; potent analgesics and anti-inflammatory agents | ROTTAPHARM S.P.A. (IT) | 2011-06-28 | — | — | US | disclosed |
| EP-2057148-B1 | AMIDINE DERIVATIVES OF 2-HETEROARYL-QUINAZOLINES AND QUINOLINES; POTENT ANALGESICS AND ANTI-INFLAMMATORY AGENTS | ROTTAPHARM SPA (IT) | 2009-12-30 | — | — | EP | disclosed |
| EP-2057148-B1 | AMIDINE DERIVATIVES OF 2-HETEROARYL-QUINAZOLINES AND QUINOLINES; POTENT ANALGESICS AND ANTI-INFLAMMATORY AGENTS | ROTTAPHARM SPA (IT) | 2009-12-30 | — | — | EP | disclosed |
| US-20090227609-A1 | AMIDINE DERIVATIVES OF 2-HETEROARYL-QUINAZOLINES AND QUINOLINES; POTENT ANALGESICS AND ANTI-INFLAMMATORY AGENTS | ROTTAPHARM S.P.A. (IT) | 2009-09-10 | — | — | US | disclosed |
| US-20090227609-A1 | AMIDINE DERIVATIVES OF 2-HETEROARYL-QUINAZOLINES AND QUINOLINES; POTENT ANALGESICS AND ANTI-INFLAMMATORY AGENTS | ROTTAPHARM S.P.A. (IT) | 2009-09-10 | — | — | US | disclosed |
| US-20090227609-A1 | AMIDINE DERIVATIVES OF 2-HETEROARYL-QUINAZOLINES AND QUINOLINES; POTENT ANALGESICS AND ANTI-INFLAMMATORY AGENTS | ROTTAPHARM S.P.A. (IT) | 2009-09-10 | — | — | US | disclosed |
| WO-2008014815-A1 | AMIDINE DERIVATIVES OF 2-HETEROARYL-QUINAZOLINES AND QUINOLINES; POTENT ANALGESICS AND ANTI-INFLAMMATORY AGENTS | ROTTAPHARM S.P.A. (IT) | 2008-02-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090227609-A1 | AMIDINE DERIVATIVES OF 2-HETEROARYL-QUINAZOLINES AND QUINOLINES; POTENT ANALGESICS AND ANTI-INFLAMMATORY AGENTS | NOS2, NOS3, NOS1 | MAOA 455/4885MAOB 414/4885CYP1A2 28/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.