Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 3/20 | 0.42 |
| ▸ | MAOB | P27338 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.39 |
| ▸ | PIR | O00625 | 1/20 | 0.38 |
| ▸ | HSF1 | Q00613 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.38 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.38 |
| ▸ | ERN1 | O75460 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1748935 | 0.99 | MAOA (0.42) | MAOAMAOBNPC1RAB9ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL1747914 | 0.98 | MAOA (0.41) | MAOAMAOBNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1747910 | 0.94 | PIR (0.44) | MAOAMAOBNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1747929 | 0.92 | MAOA (0.42) | MAOAMAOBNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1748533 | 0.88 | MAOA (0.54) | MAOAMAOBNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4405483 | 0.86 | MAOA (0.37) | MAOAMAOBNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1747918 | 0.84 | MAOA (0.54) | MAOAMAOBNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1752263 | 0.83 | RAB9A (0.48) | MAOAMAOBNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1747962 | 0.81 | MAOA (0.39) | MAOAMAOBNPC1RAB9AKDM4E | |
| SCHEMBL12527170 | 0.80 | GABRA2 (0.34) | MAOAMAOBKDM4EFLT3FGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7968558-B2 | Amidine derivatives of 2-heteroaryl-quinazolines and quinolines; potent analgesics and anti-inflammatory agents | ROTTAPHARM S.P.A. (IT) | 2011-06-28 | — | — | US | disclosed |
| US-7968558-B2 | Amidine derivatives of 2-heteroaryl-quinazolines and quinolines; potent analgesics and anti-inflammatory agents | ROTTAPHARM S.P.A. (IT) | 2011-06-28 | — | — | US | disclosed |
| US-7968558-B2 | Amidine derivatives of 2-heteroaryl-quinazolines and quinolines; potent analgesics and anti-inflammatory agents | ROTTAPHARM S.P.A. (IT) | 2011-06-28 | — | — | US | disclosed |
| EP-2057148-B1 | AMIDINE DERIVATIVES OF 2-HETEROARYL-QUINAZOLINES AND QUINOLINES; POTENT ANALGESICS AND ANTI-INFLAMMATORY AGENTS | ROTTAPHARM SPA (IT) | 2009-12-30 | — | — | EP | disclosed |
| US-20090227609-A1 | AMIDINE DERIVATIVES OF 2-HETEROARYL-QUINAZOLINES AND QUINOLINES; POTENT ANALGESICS AND ANTI-INFLAMMATORY AGENTS | ROTTAPHARM S.P.A. (IT) | 2009-09-10 | — | — | US | disclosed |
| US-20090227609-A1 | AMIDINE DERIVATIVES OF 2-HETEROARYL-QUINAZOLINES AND QUINOLINES; POTENT ANALGESICS AND ANTI-INFLAMMATORY AGENTS | ROTTAPHARM S.P.A. (IT) | 2009-09-10 | — | — | US | disclosed |
| US-20090227609-A1 | AMIDINE DERIVATIVES OF 2-HETEROARYL-QUINAZOLINES AND QUINOLINES; POTENT ANALGESICS AND ANTI-INFLAMMATORY AGENTS | ROTTAPHARM S.P.A. (IT) | 2009-09-10 | — | — | US | disclosed |
| WO-2008014815-A1 | AMIDINE DERIVATIVES OF 2-HETEROARYL-QUINAZOLINES AND QUINOLINES; POTENT ANALGESICS AND ANTI-INFLAMMATORY AGENTS | ROTTAPHARM S.P.A. (IT) | 2008-02-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090227609-A1 | AMIDINE DERIVATIVES OF 2-HETEROARYL-QUINAZOLINES AND QUINOLINES; POTENT ANALGESICS AND ANTI-INFLAMMATORY AGENTS | NOS2, NOS3, NOS1 | MAOA 455/4885MAOB 414/4885NPC1 2921/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.