Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 3/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.39 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.39 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17322787 | 0.81 | GAA (0.59) | GAAKDM4EMAPTCA2HTR6 | |
| SCHEMBL13242744 | 0.81 | KDM4E (0.50) | GAAKDM4EMAPTCA2HTR6 | |
| SCHEMBL8149846 | 0.80 | CA2 (0.64) | GAAKDM4EMAPTCA2HTR6 | |
| SCHEMBL14845761 | 0.80 | GAA (0.61) | GAAKDM4EMAPTCA2HTR6 | |
| SCHEMBL4889389 | 0.78 | GAA (0.59) | GAAKDM4EMAPTCA2HTR6 | |
| SCHEMBL9676821 | 0.78 | GAA (0.59) | GAAKDM4EMAPTCA2HTR6 | |
| SCHEMBL30116330 | 0.78 | GAA (0.59) | GAAKDM4EMAPTCA2HTR6 | |
| SCHEMBL15631840 | 0.77 | GAA (0.57) | GAAKDM4EMAPTCA2HTR6 | |
| SCHEMBL10048751 | 0.77 | GAA (0.57) | GAAKDM4EMAPTCA2HTR6 | |
| SCHEMBL15075265 | 0.75 | GAA (0.55) | GAAKDM4EMAPTCA2HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160030457-A1 | TUMOR-SELECTIVE COMBINATION THERAPY | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2016-02-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160030457-A1 | TUMOR-SELECTIVE COMBINATION THERAPY | NQO1, KEAP1, MCL1 | GAA 1004/4885KDM4E 4071/4885MAPT 3726/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.