SCHEMBL17499504

SCHEMBL17499504

CC(=Nc1ccccc1O[SiH](C)C)c1ccncn1

nearest known ligand 0.35

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
HKDC1 Q2TB90 2/20 0.34
HSP90AA1 P07900 1/20 0.34
ALDH1A1 P00352 2/20 0.34
LMNA P02545 1/20 0.34
MAPT P10636 1/20 0.34
HSD17B10 Q99714 1/20 0.34
CTNNB1 P35222 1/20 0.34
WNT3A P56704 1/20 0.34
KDM4E B2RXH2 1/20 0.33
TBXA2R P21731 4/20 0.32
CCR8 P51685 3/20 0.32
KCNH2 Q12809 3/20 0.32
P2RX7 Q99572 1/20 0.32
RAB9A P51151 2/20 0.32
SMN1; SMN2 Q16637 1/20 0.31
GRM4 Q14833 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17499688 0.86 TBXA2R (0.45) ALDH1A1LMNAMAPTCTNNB1WNT3A
SCHEMBL17499126 0.85 KDM4E (0.50) HKDC1ALDH1A1LMNAMAPTKDM4E
SCHEMBL17499520 0.85 ALDH1A1 (0.47) HKDC1HSP90AA1ALDH1A1LMNAMAPT
SCHEMBL17499467 0.83 POLB (0.38) HSP90AA1MAPTKDM4ERAB9ASMN1; SMN2
SCHEMBL17499456 0.82 HKDC1 (0.35) HKDC1HSP90AA1ALDH1A1LMNAMAPT
SCHEMBL17499124 0.82 GAA (0.37) ALDH1A1LMNAMAPTHSD17B10KDM4E
SCHEMBL17499675 0.82 KDM4E (0.32) ALDH1A1LMNAMAPTHSD17B10KDM4E
SCHEMBL17499490 0.82 ALDH1A1 (0.33) ALDH1A1LMNAMAPTHSD17B10KDM4E
SCHEMBL17499527 0.80 KDM4E (0.37) HKDC1HSP90AA1ALDH1A1LMNAMAPT
SCHEMBL17499219 0.79 HKDC1 (0.36) HKDC1HSP90AA1ALDH1A1LMNAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2969593-B1 POLYMERS FUNCTIONALIZED WITH HETEROCYCLIC IMINES BRIDGESTONE CORP (JP) 2020-11-04 EP disclosed
US-9850328-B2 Polymers functionalized with heterocyclic imines BRIDGESTONE CORPORATION (JP) 2017-12-26 US disclosed
US-20160039958-A1 Polymers Functionalized With Heterocyclic Imines BRIDGESTONE CORPORATION (JP) 2016-02-11 US disclosed