Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | USP2 | O75604 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CNR1 | P21554 | 3/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | CCR8 | P51685 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28853128 | 0.87 | TSHR (0.54) | KMT2AMEN1GAAALDH1A1NPSR1 | |
| SCHEMBL29467287 | 0.85 | CNR1 (0.51) | KMT2AMEN1GAAPOLBALDH1A1 | |
| SCHEMBL1256021 | 0.85 | CNR1 (0.51) | KMT2AMEN1GAAPOLBALDH1A1 | |
| SCHEMBL17502106 | 0.80 | KMT2A (0.50) | KMT2AMEN1GAAPOLBALDH1A1 | |
| SCHEMBL1990490 | 0.78 | ALDH1A1 (0.61) | KMT2AMEN1GAAPOLBALDH1A1 | |
| SCHEMBL17478912 | 0.78 | KDM4E (0.46) | KMT2APOLBALDH1A1KDM4ENPSR1 | |
| SCHEMBL22714758 | 0.76 | ALDH1A1 (0.59) | KMT2AMEN1GAAPOLBALDH1A1 | |
| SCHEMBL17593030 | 0.75 | BCAT2 (0.49) | ALDH1A1KDM4EMAPTHSD17B10PARP1 | |
| SCHEMBL1987895 | 0.74 | CNR1 (0.54) | KMT2AMEN1GAAPOLBALDH1A1 | |
| SCHEMBL16102708 | 0.74 | EDNRA (0.48) | PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170136030-A1 | TREATMENT OF MALARIA USING INHIBITORS OF THE ISPD ENZYME IN THE NON-MEVALONATE PATHWAY | WASHINGTON UNIVERSITY (US) | 2017-05-18 | — | — | US | disclosed |
| US-20160046651-A1 | TREATMENT OF MALARIA USING INHIBITORS OF THE ISPD ENZYME IN THE NON-MEVALONATE PATHWAY | UNIV WASHINGTON (US) | 2016-02-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160046651-A1 | TREATMENT OF MALARIA USING INHIBITORS OF THE ISPD ENZYME IN THE NON-MEVALONATE PATHWAY | IMPDH1, IMPDH2, SHMT2 | KMT2A 2156/4885MEN1 2920/4885GAA 816/4885 |
| US-20170136030-A1 | TREATMENT OF MALARIA USING INHIBITORS OF THE ISPD ENZYME IN THE NON-MEVALONATE PATHWAY | IMPDH1, IMPDH2, SHMT2 | KMT2A 2156/4885MEN1 2920/4885GAA 816/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.