Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA5A | P35218 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.39 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6852237 | 0.87 | MEN1 (0.41) | LMNAKMT2AMEN1THRBBLM | |
| SCHEMBL12004564 | 0.79 | LMNA (0.50) | LMNAKMT2AMEN1THRBBLM | |
| SCHEMBL29417728 | 0.79 | NFKB1 (0.57) | LMNAKMT2AMEN1THRBBLM | |
| SCHEMBL67207 | 0.79 | NFKB1 (0.57) | LMNAKMT2AMEN1THRBBLM | |
| SCHEMBL17508341 | 0.77 | LMNA (0.43) | LMNAKMT2AMEN1THRBBLM | |
| SCHEMBL10670263 | 0.76 | LMNA (0.46) | LMNAKMT2AMEN1THRBBLM | |
| SCHEMBL17508181 | 0.76 | KMT2A (0.46) | LMNAKMT2AMEN1THRBBLM | |
| SCHEMBL5350677 | 0.75 | LMNA (0.50) | LMNAKMT2AMEN1THRBBLM | |
| SCHEMBL17103316 | 0.75 | LMNA (0.50) | LMNAKMT2AMEN1THRBBLM | |
| SCHEMBL22620679 | 0.75 | LMNA (0.50) | LMNAKMT2AMEN1THRBBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016019588-A1 | OXACAZONE COMPOUNDS TO TREAT CLOSTRIDIUM DIFFICILE | THE BROAD INSTITUTE, INC. (US) | 2016-02-11 | — | — | WO | disclosed |